Oral mucosa: variations from normalcy, part I.

Many lesions can be identified in the oral mucosa. Some are indicative of pathologic conditions restricted to the oral cavity, whereas others are signs of systemic disorders. A third group of alterations is not severe enough to be considered pathologic; however, knowledge of this group is mandatory for a correct differential diagnosis to be established. This is the first article in a 2-part series concerning all of these pseudopathologic conditions.

[Laugier-Hunziker syndrome. A clinical and anatomopathologic study. Presentation of 13 cases]. / Syndrome de Laugier-Hunziker. Etude clinique et anatomopathologique. Présentation de treize cas.

We report the clinico-pathologic characteristics of 13 cases of Laugier-Hunziker disease, consisting of the presence of oral melanotic macules associated or not to longitudinal nail pigmentation. The presence of regular acanthosis, basal pigmentation without increase in the number of melanocytes and the presence of melanophages in subepidermal connective tissue have been the most constant histopathological characteristics. The term "essential cutaneo-mucous hyperpigmentation" as synonym of Laugier-Hunziker disease is proposed.

Dark oral lesions: differential diagnosis with oral melanoma.

Oral melanoma is a neoplasm with a poor prognosis; its premature diagnosis is of foremost importance. We review here pathologic situations to be considered in the clinical differential diagnosis: tattoos, melanotic macules, Laugier's disease, melanocytic nevus, drug intake, some vascular lesions, and oral pigmented lesions associated with endocrine disorders or with different syndromes.

[Toxic epidermal necrolysis associated with lymphoproliferative syndromes. Anatomo-clinical study. Presentation of 2 cases]. / Nécrolyse épidermique toxique associée à des syndromes lymphoprolifératifs. Etude anatomo-clinique. Présentation de deux cas.

Two cases of Toxic Epidermal Necrolysis, with a previous history of drugs intake, and associated to a lymphoma and to a chronic lymphoid leukemia, are presented. The oral lesions are described and the clinical and pathological particularities of the cases are commented. The rule of the drugs and of the neoplastic diseases in the aetiology of these cases is discussed. In conclusion, we emphasize the N.E.T. as an entity of stomatological interest.

[Oral herpes virus infection in immunodepressed patients: presentation of 2 cases. Review of the literature]. / Infección oral por herpes virus en pacientes inmunodeprimidos: presentación de 2 casos. Revisión de la literatura.

Two cases of herpetic intraoral infection, in inmunodepressed patients, are presented. We emphasize its diagnosis and therapeutical aspects. A bibliographic review is done.

[Lichen planus of the oral mucosa in the clinical course of chronic active hepatitis. Presentation of two cases]. / Liquen plano de la mucosa oral en el curso clínico de hepatitis crónica activa. Presentación de dos casos.

Two cases of oral lichen planus associated with chronic active hepatitis are presented. One of them it was also associated with achrosclerosis. A review of the literature is done, and it is suggested the possibility that oral lichen planus play a role of diagnostic importance in hepatic pathology.

[Dental caries in 2 families with tuberous sclerosis]. / Puits dentaires dans deux familles avec sclérose tubéreuse.

Four cases of tuberous sclerosis in two families are presented. We studied the oral manifestations of the disease and we suggest that dental pits should be taken as clinical markers for diagnosis in oligosymptomatic cases. We found that feature in all patients affected by tuberous sclerosis.

[Radioprotective effect of ascorbic acid on oral structures in patients with cancer of the head and neck]. / Efecto radioprotector del acido ascorbico sobre estructuras orales en pacientes con cancer de cabeza y cuello.

It is considered the radioprotective effect of ascorbic acid in patients with head and neck cancer. It is observed a reduction of yatrogenic effects over oral structures secondary to radiotherapy. It is recommended the oral administration of ascorbic acid in this type of patients.

[Oral manifestations in tuberous sclerosis. Report of 3 cases]. / Manifestaciones orales en esclerosis tuberosa. Presentación de tres casos.

We present three cases of Tuberous Sclerosis, studying its oral manifestations and suggesting that dental pits are clinical markers of diagnostic interest in the paucisymptomatic forms of the syndrome.

[Detection of human papillomavirus antigens in papillomatous lesions of the palate]. / Detección de antigenos de Papilomavirus humano (HPV) en lesiones papilomatosas del paladar.

The presence of human papillomavirus antigen was studied in palate papillomas and in verruca vulgaris located in the palate using the Peroxidase-Antiperoxidase immunohistochemical methods. The antigens were detected only in the nuclei of cells of the stratum granulosum and stratum corneum in some cases of verruca vulgaris but not in any case of palate papillomas.