1.
J Antibiot (Tokyo)
; 65(8): 437-40, 2012 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22922478
Assuntos
Basidiomycota/química , Ergosterol/análogos & derivados , Ergosterol/farmacologia , Elastase de Leucócito/antagonistas & inibidores , Ergosterol/química , Humanos , Concentração Inibidora 50 , Elastase de Leucócito/metabolismo , Espectroscopia de Ressonância Magnética , Espectrometria de Massas , Estrutura Molecular , Micélio/química , Rotação Ocular , Espectrofotometria Infravermelho
2.
Molecules
; 14(1): 266-72, 2009 Jan 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19136914
RESUMO
Activity-guided fractionation of a MeOH extract of the roots of Saussurea lappa C.B.Clarke (Compositae), using an in vitro protein tyrosine phosphatase 1B (PTP1B) inhibition assay, led to the isolation of four active constituents: betulinic acid (1), betulinic acid methyl ester (2), mokko lactone (3) and dehydrocostuslactone (4), along with nine inactive compounds. Our findings indicate that betulinic acid (1) and its methyl ester 2, as well as the two guaiane sesquiterpenoids 3 and 4 are potential lead moieties for the development of new PTP1B inhibitors.