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Int Immunopharmacol ; 112: 109183, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-36182877

RESUMO

SARS-CoV-2 infection can produce a variety of clinical manifestations, which are either directly related to viral tissue damage or indirectly induced by the antiviral immune response. Molecular mimicry enables this virus to undermine self-tolerance in a host's immune system also immune system's attempts to eliminate SARS-COV-2 may trigger autoimmunity by hyper-activating the innate and adaptive immune systems. Auto immune diseases include Systemic lupus erythematosus, autoimmune thyroid diseases, Guillain-Barre syndrome, Immune thrombocytopenic purpura, and the detection of autoantibodies are the cues to the discovery of the potential of COVID-19 in inducing autoimmunity. As COVID-19 and autoimmune diseases share a common pathogenesis, autoimmune drugs may be an effective treatment option. Susceptible patients must be monitored for autoimmune symptoms after contracting CVID-19. In light of the SARS-COV-2 virus' ability to induce autoimmunity in susceptible patients, will the various COVID-19 vaccines that are the only way to end the pandemic induce autoimmunity?


Assuntos
Doenças Autoimunes , COVID-19 , Púrpura Trombocitopênica Idiopática , Humanos , SARS-CoV-2 , Mimetismo Molecular , Vacinas contra COVID-19 , Antivirais , Autoanticorpos , Sistema Imunitário
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