Triazolo[4,5-f]quinolines. Part VI. Synthesis and evaluation of 9-aminoalkyl(aryl)-2-methyl-2H-[4,5-f]quinolines as anticancer agents. Preliminary results of in vitro screening.

9-Aminoalkyl(aryl)-2-methyl-2H-triazolo[4,5-f] quinolines were prepared in order to evaluate their in vitro antitumor activity. Some members of this series exhibited both cell selectivity and tumor growth inhibition activity at concentrations between 10(-8) and 10(-4)M. In particular, compounds Ia,c,m,o,p and q showed percent growth near zero at midpoint between 10(-5) and 10(-4)M in most cell lines.