RESUMO
Superior vena cava syndrome (SVCS) is mostly presented in advanced stage of lung cancer. Similar symptoms may misdirect correct diagnosis, especially in nonmalignant cases of SVCS. In the fifties of the 20th century, mediastinitis caused by tuberculosis and syphilis were dominant causes of non-malignant SVCS. Currently, non-cancer causes of SVCS are responsible for 5% to 22% of all SVCS cases. In most cases inner obliteration of the vessel is a result of thrombosis at the site of endothelial injury caused by either intravascular devices (catheters, electrodes). Clinical signs are nonspecific particularly in acute course of syndrome. We present a case of a men with edema of the lower part of the head and neck, as a pseudo allergic acute reaction, where eventually diagnosis of acute superior vena cava syndrome due to ascending aorta aneurysm was established. Based on the case, review of nonmalignant causes of SVCS and treatment options are discussed.
Assuntos
Aneurisma Aórtico/complicações , Síndrome da Veia Cava Superior/etiologia , Idoso , Aneurisma Aórtico/diagnóstico , Diagnóstico Diferencial , Humanos , Neoplasias Pulmonares/diagnóstico , Masculino , Síndrome da Veia Cava Superior/diagnósticoRESUMO
BACKGROUND/AIMS: Renalase is a recently discovered protein, which is likely involved in regulation of blood pressure in humans and animals. Previous studies suggest that renalase reflects kidney functioning. A common missense polymorphism in the flavin-adenine dinucleotide-binding domain of human renalase (Glu37Asp) has been described. In this study we examined the association between (Glu37Asp) polymorphism (rs2296545) in renalase gene and kidney allograft function. METHODS: The study enrolled 270 Caucasian kidney allograft recipients. SNP within the renalase was genotyped using TaqMan genotyping assays. RESULTS: There were no statistically significant associations between renalase gene rs2296545 polymorphism and delayed graft function, acute rejection, chronic allograft dysfunction as well as creatinine serum concentrations and blood pressure values after transplantation. CONCLUSIONS: The results of this study suggest, that renalase gene rs2296545 polymorphism is not important factor determining renal allograft function.
