[Morphofunctional changes of BALB/c and C57BL/6 mice's immune system under chronic bacterial gram-negative endotoxicosis].

Chronic endotoxicosis was modeled by subcutaneous injection of the sepharose in complex with LPS. In these conditions we have studied morphofunctional changes of the immune system of BALB/c and C57Bl/6 mice, which are characterized by the different types of the immune response (Th2 type is predominant in BALB/c, Th1--in C57Bl/6). In the 1st-7th day t in the serum of BALB/c mice the endotoxin level increased in 21.3 times, in C57Bl/6--in 20.6 times. The endotoxin antibodies significantly decreased in 1th-7th days, on the 14th day it increased in the serum of both mice's strains. Morphofunctional changes of the immune system after chronic endotoxicosis were different in BALB/c and C57BI/6 mice. On the 1th day after injection of LPS and sepharose, in the thymus of C57Bl/6 mice the cortex layer was exhausted because of cell death, in the thymus of BALB/c mice II-III stages of accidental involution were developed. On the 7-14th day after injection of LPS and sepharose in the spleen of C57Bl/6 mice T- and B-zones were hyperplastic, however in spleen of BALB/c mice only T-zone were enlarged. After LPS and sepharose injection changes of cytokine production synthesized by KonA activated splenic cells were found out. In both strains the level of proinflammatory cytokines--TNFalpha and IL-1beta decreased, as well the Th1-cytokine IL-2. The production o fTh2-cytokine - IL-4, significantly decreased only in C57BI/6 mice. We suggest that damaging effect of LPS injection is determined by predominant Th2 or Th2 types of the immune response.

[Specific features of night acidity in patients with peptic duodenal ulcers and primary chronic gastroduodenitis]. / Osobennosti nochnogo kisloobrazovaniia u bol'nykh iazvennoi bolezn'iu.

The peculiarities of nightly acid formation in the patients with peptic ulcer (PU) and primary chronic gastroduodenitis (PCG) were examined with apparatus "Gastroskan-24", that has computer's program to evaluate the data of intragastric 24-hours pH measurement. 24 patients with PU and 36 patients with PCG were examined. The increase of nightly acid formation was higher in the patients with PU versus the patients with PCG. It was revealed that pH depends on smoking. The possibility of risk group to peptic ulcer definition was demonstrated in patients with PCG.

[The use of cryomassage in the rehabilitative treatment of patients with duodenal peptic ulcer at the polyclinic stage]. / Primenenie kriomassazha v vosstanovitel'nom lechenii bol'nykh iazvennoi bolezn'iu dvenadtsatiperstnoi kishki na poliklinicheskom étape.

The proposed technique of cryomassage in outpatient setting promotes a complete healing of duodenal ulcer (DU) in patients with DU exacerbation. Healing of the ulcer is accompanied by improvement of blood flow in the zones of segmental innervation of the gastroduodenal system and by recovery of impaired cellular and humoral immunity in most of the patients.

[Interference currents in the treatment of patients with duodenal peptic ulcer]. / Interferentsionnye toki v lechenii bol'nykh iazvennoi bolezn'iu dvenadtsatiperstnoi kishki.

93 patients with duodenal ulcer were exposed to interference currents (transcerebral and epigastric exposure). These currents were found clinically and functionally effective. The improvement was also found in the trophic processes in the gastroduodenal area. Gastroduodenal mucosa contamination with Helicobacter pylori reduced.

[Non-medicinal methods of correction of immune disorders in peptic ulcer patients]. / Nemedikamentoznye metody korrektsii immunnykh narushenii u bol'nykh iazvennoi bolezn'iu.

The authors provide the immunological and radioimmunological data on 148 patients suffering from duodenal ulcer different in size. Material alterations were revealed in the cellular and humoral components of immunity and in the pituitary-thyroid system. Based on the investigations carried out it has been shown that natural therapeutic factors, namely mud applications made according to an original method, being mediated via the endocrine system stimulate the cellular component of immunity, reduce the degree of autoaggression, counteract imbalance of the humoral component of immunity, thereby promoting the acceleration of the restorative and regenerative processes in patients suffering from duodenal ulcer.

[The use of physical factors on the neck area in gastric and duodenal peptic ulcer]. / Primenenie fizicheskikh faktorov na vorotnikovuiu oblast' pri iazvennoi bolezni zheludka i dvenadtsatiperstnoi kishki.

Basing on examination of 54 peptic ulcer patients and 62 patients operated on for duodenal ulcer it was shown that collar region is functionally active. In response to physical factors it promotes better regulation of pituitary and thyroid function as shown by radioimmunoassay, thermography and other modern investigating techniques. The findings support administration of physiotherapy on collar region for correction of neurohumoral regulation, trophicity and function of the stomach in ulcer patients.

[Effect of potable mineral waters with various chemical compositions on reparative processes of the mucosa of the gastroduodenal area]. / Vliianie pit'evykh mineral'nykh vod razlichnogo khimicheskogo sostava na reparativnye protsessy slizistoi obolochki gastroduodenal'noi oblasti.

Examinations covered patients recovering after gastroduodenal ulcer exacerbation treated with oral mineral waters of different chemical composition. Drinking mineral water was found to stimulate trophic processes in gastroduodenal mucosa, more pronounced for waters of complex chemical composition, e. g. Moscow calcium-magnesium-sodium sulfate water.