[Coverage of issues of professional malignant neoplasms of the respiratory tract in modern clinical guidelines of the Ministry of Health of Russia]. / Osveshchenie voprosov professional'nykh zlokachestvennykh novoobrazovanii respiratornogo trakta v sovremennykh klinicheskikh rekomendatsiyakh Minzdrava Rossii.

OBJECTIVE: Analysis and comparison of clinical guidelines (CG) on malignant neoplasms of the respiratory system, placed in the CG rubricator of the Ministry of Health of Russia, for the information they contain on the role of factors and working conditions of the working environment in the etiology of respiratory diseases, including the upper respiratory tract, and comparison this information with published and regularly updated data from the International Agency for Research on Cancer (IARC). MATERIAL AND METHODS: Clinical recommendations from the heading of the Ministry of Health of Russia "Cancer of the laryngopharynx", "Cancer of the nasopharynx", "Cancer of the oropharynx", "Cancer of the nasal cavity and paranasal sinuses", "Cancer of the larynx", "Cancer of the trachea", "Cancer of the lung", and IARC data according to the List of Classifications by cancer sites with sufficient or limited evidence in humans dated 11/29/2019. RESULTS: The low level of registration of occupational cancer of the upper respiratory tract in Russia is due to an inadequate system of criteria for detecting this form of occupational pathology, a long latency period of diseases, and insufficient assessment of the history of information on the potential role of occupational carcinogens. The CGs developed to optimize the diagnosis and treatment of malignant neoplasms of the respiratory system do not contain up-to-date information on the role of professional potential carcinogens in the genesis of malignant neoplasms. CONCLUSION: Recognition of the professional nature of malignant neoplasms of the respiratory system implies, firstly, strengthening the role of otorhinolaryngologists in early diagnosis and rehabilitation of patients, and secondly, it has a pronounced preventive focus in the form of tasks facing the employer to reduce the carcinogenic load and develop preventive measures aimed to reduce and prevent the development of malignant tumors in workers, including the respiratory system.

[Upper respiratory tract infection with new COVID-19 coronavirus infection and aspects of occupational pathology examination]. / Porazhenie verkhnikh dykhatel'nykh putei novoi koronavirusnoi infektsiei COVID-19 i aspekty profpatologicheskoi ekspertizy.

The article discusses the issues of a new coronovirus infection CAVID-19, which suddenly appeared from the end of January 2020. in China and actively, widely spread around the world. The SARS-CoV virus is assigned to group II pathogenicity. The entrance gate of the pathogen is the epithelium of the VDP and epithelial cells of the stomach and intestines. The main source of infection is a sick person who transmits SARS-CoV-2 by airborne droplets and contact. There is a high risk of developing epidemic foci CAVID-19 in medical institutions in case of violation of sanitary and anti-epidemic regime and the risk of epidemic foci in groups of organizations with non-compliance with infection prevention measures. On the basis of the Decree of the President of the Russian Federation dated may 06. 2020 №313 of the Ministry of health of the Russian Federation, together with the FSS and Rospotrebnadzor, additional insurance guarantees are provided to doctors, middle and Junior medical personnel of medical organizations, drivers of ambulances who work directly with patients who have confirmed the presence of a new coronavirus infection (COVID-19). Insurance cases, when a one-time insurance payment is made, are persistent loss of working capacity by a medical worker as a result of complications after a previous illness caused by a new coronavirus infection (COVID-19), confirmed by laboratory research methods, if the disease occurred during the performance of their work duties.

[Adaptation potential of cardio-respiratory system in dust diseases].

The article covers results of cardio-respiratory system evaluation in workers exposed to dust, on basis of adaptation potential evaluation via calculation of functional changes index and 6 minutes' walk test with continuous assessment of blood oxygenation and heart rate. Adaptation disorders are supported by results of external respiration assessment and echo-cardiography.

[Clinical and hygienic evaluation of health state of copper production workers in Far North].

The article covers disclosure of fuctional and clinical, laboratory markers of health disorders among workers engaged in major occupations of copper processing enterprise. These markers are used for early diagnosis and prevention of respiratory diseases.

[FEDERAL CLINICAL PRACTICE GUIDELINES FOR THE DIAGNOSIS, PREVENTION AND TREATMENT OF PNEUMOCONIOSIS].

The purpose of development of this clinical practice guidelines was to provide evidence-based protocols that help the practitioner and the patient make the right decision for the health assessment, treatment and prevention of pneumoconiosis. Pneumoconiosis is the interstitial lung disease of occupational origin caused by prolonged inhalation of inorganic dust, characterized by chronic diffuse aseptic inflammation in lung tissue with the development of pulmonary fibrosis. Currently, thereare no treatment that provide a cure pulmonary fibrosis and changes in the dynamics of decline in lung function. Regular, individually tailored treatment should be directed to the pathogenic mechanisms and some clinical symptoms of pneumoconiosis, as well as the prevention of complications. To enhance the effect of pharmacotherapy is recommended to use non-drug therapies that enhance the functionality of the respiratory system.

[Responsiveness of peripheral blood neutrophils under exposure to industrial aerosols].

There was made an evaluation of the functional state of peripheral blood neutrophils in 230 workers with dustbreathing risks (mine, metallurgical and machine-building works). There was noted the change in the responsiveness of neutrophils in dependence on both composition and the intensity of the exposure of industrial aerosols to the human body. There was followed the relation between the pathology of the respiratory system with the biochemical changes of granulocytes. These data can be used for the assessment of the nonspecific body resistance in the development of dust lung diseases.

[Retrospective analysis of primary disability among employees of enterprises for the production of technical ceramics].

On the example of588 disability cases registered in employees of the plant for the production of technical ceramics during the 1975-2014 the analysis of the dynamics of illness, gender and age structure of disability indices on the main Origlnarartlcie and auxiliary units of the enterprise was executed for the interval of 10 years periods. There were followed trends in the alteration of the structure of the disability caused by the socio-economic, hygienic and demographic factors.

[The methodological approaches to the evaluation of the risk of developing pathology of the upper respiratory tract in the employees engaged in the dust-producing industries].

The objective of the present work was to develop the scientifically sound criteria for the evaluation of the occupational risks bearing in mind the high frequency of pathological changes in the ciliary epithelium of the upper respiratory tract in the employees engaged in the dust-producing industries. It was proposed to consider an increase of the SIgA level, alkaline shift in nasal secretion pH, elevation of body temperature, slowdown of the mucociliary transport, disintegration of the epithelial mucous membrane, and high frequency of its inflammatory and dystrophic changes as the criteria for early diagnostics of developing pathology of the upper respiratory tract. We have developed the method for the score-based evaluation of the risk of formation of pathological changes in the upper respiratory tract of the employees engaged in the dust-producing industries. This method can be used to enhance the effectiveness of the preventive and health-promoting measures.