RESUMO
Treatment results of 203 patients with critical ischemia by neuroischemic form of the diabetic foot sindrome were analyzed. 45 patients had open, endovascular or hybrid vascular reconstructions. The method was decised basing on the results of angiographic studies. The support function was saved in 34 (75,6%) cases of 45 operated patients. Revascularization proved to be an effective and reasonable method of surgical intervention by critical ischemia caused by the neuroischemic form of the diabetic foot syndrome.
Assuntos
Complicações do Diabetes/prevenção & controle , Pé Diabético/cirurgia , Gangrena/cirurgia , Isquemia/cirurgia , Procedimentos Cirúrgicos Vasculares/métodos , Idoso , Amputação Cirúrgica/estatística & dados numéricos , Angiografia , Circulação Sanguínea , Estado Terminal , Complicações do Diabetes/fisiopatologia , Pé Diabético/etiologia , Pé Diabético/fisiopatologia , Feminino , Pé/irrigação sanguínea , Gangrena/etiologia , Gangrena/fisiopatologia , Humanos , Isquemia/etiologia , Isquemia/fisiopatologia , Masculino , Pessoa de Meia-Idade , Administração dos Cuidados ao Paciente , Equipe de Assistência ao Paciente , Recuperação de Função Fisiológica , Resultado do Tratamento , Grau de Desobstrução Vascular , Procedimentos Cirúrgicos Vasculares/efeitos adversos , Procedimentos Cirúrgicos Vasculares/normas , Procedimentos Cirúrgicos Vasculares/estatística & dados numéricosRESUMO
The article deals with diabetic foot syndrome defined as a multidisciplinary problem. A reconstructive vascular operation in critical ischaemia on the background of diabetic foot syndrome is herein shown to be an efficient and justified intervention. Revascularization makes it possible to carry out sparing resections on the foot, to appropriately cope with the events of lower-limb critical ischaemia, and to reliably decrease the rate of high amputations.
Assuntos
Pé Diabético/cirurgia , Isquemia/cirurgia , Perna (Membro)/irrigação sanguínea , Procedimentos Cirúrgicos Vasculares/métodos , Idoso , Idoso de 80 Anos ou mais , Amputação Cirúrgica , Pé Diabético/complicações , Seguimentos , Humanos , Isquemia/etiologia , Perna (Membro)/cirurgia , Pessoa de Meia-Idade , Estudos Retrospectivos , Síndrome , Resultado do TratamentoRESUMO
The study was performed of mitotic cycle stage distribution (G1/0, S, G2 + M) by means of flow cytometry in rats irradiated locally and totally and in 25 cancer patients receiving radiotherapy. Radiation effects manifested themselves in diminished percentage of cells in S-stage, in the block G2 + M reflecting the direct affection of myelokaryocytes. Logarithmic dependence of the quantity, of cells synthetizing DNA on radiation dose occurred in the animals in the range 0.5-6 Gy 24 hours after the exposure. Investigation of the patients' sternal puncture biopsies indicated that the proportion of S-stage cells and the value S/(G2 + M) are significant diagnostic markers of more than 1 Gy irradiation 24-48 h after the exposure. For establishing radiation overdosage these parameters proved much more informative than hemocytological indices (myelogram).
Assuntos
Medula Óssea/efeitos da radiação , Índice Mitótico/efeitos da radiação , Animais , Biópsia por Agulha , Células da Medula Óssea , Relação Dose-Resposta à Radiação , Citometria de Fluxo , Doença de Hodgkin/patologia , Doença de Hodgkin/radioterapia , Humanos , Masculino , Dosagem Radioterapêutica , Ratos , Irradiação Corporal TotalRESUMO
Inactivated vaccine against tick-borne encephalitis (TBE), prepared on the basis of strain 205, is characterized by epidemiological (53%) and immunobiological activity. The appearance of a few TBE cases among the vaccinees is probably due to different maturation rate of immune response to various strains (different specificity of immune response). A suggestion has been made that no inactivated vaccine prepared from a single strain can produce a reliable protective effect because of pronounced heterogeneity of the population of TBE virus.
