Treating post-traumatic stress disorder in survivors of community and domestic violence using narrative exposure therapy: a case series in two public health centers in Rio de Janeiro/Brazil / Terapia de exposição narrativa para o tratamento do transtorno de estresse pós-traumático com pessoas que passaram por violência doméstica e comunitária: estudo de série de casos em dois centros de saúde no Rio de Janeiro, Brasil

Abstract Prevalence of violence in Brazil is high, which contributes to an increasing number of trauma-related disorders, especially post-traumatic stress disorder (PTSD). This study aims to present a case series of PTSD patients treated with narrative exposure therapy (NET) in two public health centers in Rio de Janeiro (Brazil). Health professionals were trained in a two-week workshop to deliver NET. Exposure to violence and other potentially traumatic events, as well as PTSD were assessed by interviewers before treatment and six months later in follow-up interviews conducted by blind assessors. Multiple traumatic events, including different types of childhood and sexual abuse, intimate partner violence and community violence were reported. Five patients were exposed to community violence, and one to domestic violence, during or after NET treatment. Treatment delivery was integrated into the routine of health centers. Eight patients completed NET and presented a substantial reduction in PTSD severity at six-month follow-up. NET is a feasible and effective treatment for PTSD patients exposed to ongoing violence, and can be integrated into established public health services.

Resumo A prevalência de exposição à violência é alta no Brasil, contribuindo para o aumento do número de transtornos relacionados a traumas, especialmente o transtorno de estresse pós-traumático (TEPT). Este estudo tem por objetivo apresentar uma série de casos de pacientes com TEPT que passaram pela terapia de exposição narrativa (NET) em dois centros de saúde do Rio de Janeiro. Os profissionais de saúde receberam duas semanas de treinamento NET. A exposição à violência e a outros eventos potencialmente traumáticos, bem como o TEPT, foram avaliados por entrevistadores antes do tratamento e seis meses depois em entrevistas de acompanhamento conduzidas por avaliadores sob condição cega. O tratamento foi integrado à rotina dos serviços. Oito pacientes completaram a NET e apresentaram redução substancial na severidade do TEPT. Todos reportaram exposição a eventos traumáticos múltiplos, incluindo diferentes tipos de abuso infantil, sexual, violência por parceiro íntimo e comunitária. Cinco pacientes foram expostos à violência comunitária e um à violência doméstica durante ou após o tratamento. Esta série de casos mostra que a NET é um tratamento eficaz para pacientes com TEPT expostos a violências contínuas e pode ser integrado nos serviços públicos de saúde.

Treating post-traumatic stress disorder in survivors of community and domestic violence using narrative exposure therapy: a case series in two public health centers in Rio de Janeiro/Brazil.

Prevalence of violence in Brazil is high, which contributes to an increasing number of trauma-related disorders, especially post-traumatic stress disorder (PTSD). This study aims to present a case series of PTSD patients treated with narrative exposure therapy (NET) in two public health centers in Rio de Janeiro (Brazil). Health professionals were trained in a two-week workshop to deliver NET. Exposure to violence and other potentially traumatic events, as well as PTSD were assessed by interviewers before treatment and six months later in follow-up interviews conducted by blind assessors. Multiple traumatic events, including different types of childhood and sexual abuse, intimate partner violence and community violence were reported. Five patients were exposed to community violence, and one to domestic violence, during or after NET treatment. Treatment delivery was integrated into the routine of health centers. Eight patients completed NET and presented a substantial reduction in PTSD severity at six-month follow-up. NET is a feasible and effective treatment for PTSD patients exposed to ongoing violence, and can be integrated into established public health services.

Community and domestic violence are associated with DNA methylation GrimAge acceleration and heart rate variability in adolescents.

Background: Cumulative exposure to violence can change the regulation of epigenetic and physiological markers. Although violence has been associated with accelerated cellular aging, little is known about associations with cardiac autonomic activity.Objective: The current study aimed to investigate the relationship of exposure to community and domestic violence (CDV) with vagal activity and epigenetic aging acceleration.Methods: A total of 86 adolescents (57% female) were evaluated and interviewed at two time-points in São Gonçalo (2014-2019), a Brazilian city with high levels of violence. Exposure to CDV was assessed in both time-points. GrimAge acceleration was calculated from saliva DNA methylation using Infinium HumanMethylation450K (Illumina) collected in the first assessment. Heart rate variability (HRV) was collected during two stress tasks at the second assessment.Results: The exposure to violence witnessed or directly experienced at home and in the community increased significantly (t = 4.87, p < .01) across two-time points, and males had reported higher violence exposure (t = 2.06, p = .043). Violence at 1st assessment was significantly associated with GrimAge acceleration (B = .039, p value = .043). Violence at both assessments were associated with HRV measured during the narration of the worst trauma (traumaHRV) (B = .009, p value = .039, and B = .007, p value = .024, 1st and 2nd assessment respectively). GrimAge acceleration was significantly associated with traumaHRV (B = .043, p value = .049), and HRV measured during a 3D roller coaster video (B = .061, p value = .024).Conclusions: We found relevant evidence that experiencing violence during adolescence is associated with epigenetic aging and stress-related vagal activity. Understanding these factors during this period could contribute to the development of early interventions for health promotion.HIGHLIGHTS Higher exposure to Community and domestic violence is associated with increased GrimAge acceleration.Higher GrimAge acceleration is associated with increased stress-related vagal activity.Exposure to community and domestic violence increased significantly over time.

The interplay between DNA methylation and cardiac autonomic system functioning: a systematic review.

Epigenetic marks, particularly DNA methylation (DNAm), are emerging as an important biological marker of susceptibility to cardiac autonomic dysfunction. This review summarizes recent discoveries about the association between DNAm and cardiac autonomic activity. A systematic literature search was performed through the Embase, Web of Science, Cochrane Library, Pubmed, PsycINFO, and Pilots databases. Twenty-two studies met inclusion criteria, of which 18 were human studies including a total of 2,686 participants. DNAm differences in multiple genes, such as NR3C1, TLR2, GPR133, EPO, PHGDH, OXTR, and SLC7A11, linked environmental stressors to physiological responses. For instance, exposure to psychosocial stressors increased NR3C1 methylation, which was associated with both decreased blood pressure and increased parasympathetic activity. Additionally, GPR133 played a potential role in cardiac autonomic dysfunction in an occupational setting, affecting the heart rate's deceleration capacity in welders. This review's findings suggest that DNAm is involved in cardiac autonomic regulation under different stress-mediated responses.

Curso em saúde mental no contexto da Covid-19 com povos indígenas por meio de ensino remoto / Course in mental health in the context of COVID-19 with indigenous poeples through remote learning / Curso sobre salud mental en el contexto del Covid-19 con pueblos indígenas a través del aprendizaje a distancia

Resumo O enfrentamento à Covid-19 suscitou a necessidade da formação em Saúde Mental para profissionais da saúde, educação, proteção social e lideranças comunitárias que atuam junto aos povos indígenas. Em seus cotidianos, essas comunidades já convivem com questões que impactam a saúde mental e a espiritual, mas o sofrimento psíquico ficou ainda mais evidenciado no contexto pandêmico. O curso 'Bem viver: Saúde Mental Indígena', voltado para mitigar o impacto psicossocial da Covid-19 nas populações indígenas da Amazônia brasileira, exigiu estratégias inovadoras ante o desafio de ensino remoto nesse contexto de conectividade limitada e isolamento territorial. Os desenhos pedagógico e operacional do curso priorizaram o diálogo intercultural na elaboração dos conteúdos com uso de diversas ferramentas de ensino para superar barreiras de conectividade e de entendimento da língua portuguesa no formato escrito. Apesar do desafio da produção coletiva e intercultural, dada a diversidade étnica, o curso foi um espaço de produção e trocas entre profissionais de diferentes áreas e lideranças comunitárias, sempre buscando um olhar ampliado sobre as práticas de cuidado, apoio psicossocial e valorizando as formas de atenção à saúde utilizadas pelas comunidades.

Abstract The confrontation with COVID-19 raised the need for training in Mental Health for health, education, social protection and community leaders who work with indigenous peoples. In their daily lives, these communities already live with issues that impact mental and spiritual health, but psychological distress was even more evident in the pandemic context. The 'Well Living: Indigenous Mental Health' course, aimed at mitigating the psychosocial impact of COVID-19 on indigenous populations in the Brazilian Amazon, required innovative strategies in the face of the challenge of remote learning in this context of limited connectivity and territorial isolation. The pedagogical and operational design of the course prioritized intercultural dialogue in the development of content using various teaching tools to overcome barriers to connectivity and understanding of the Portuguese language in written format. Despite the challenge of collective and intercultural production, given the ethnic diversity, the course was a space for production and exchanges between professionals from different areas and community leaders, always seeking a broader look at care practices, psychosocial support and valuing ways of health care used by communities.

Resumen La lucha contra el Covid-19 planteó la necesidad de promover la capacitación en Salud Mental para los profesionales de salud, educación, protección social y líderes comunitarios que trabajan con pueblos indígenas. En su vida diaria, estas comunidades ya conviven con problemas que impactan la salud mental y espiritual, pero el sufrimiento psíquico fue aún más evidente en el contexto de la pandemia. El curso 'Bien Vivir: Salud Mental Indígena', dirigido a mitigar el impacto psicosocial del Covid-19 en las poblaciones indígenas de la Amazonía brasileña, requirió estrategias innovadoras ante el desafío del aprendizaje remoto en un contexto de conectividad limitada y aislamiento territorial. El diseño pedagógico y operacional del curso priorizó el diálogo intercultural en el desarrollo de contenidos, utilizando diversas herramientas didácticas para superar las barreras a la conectividad y comprensión del idioma portugués en formato escrito. A pesar del desafío de la producción colectiva e intercultural, dada la diversidad étnica, el curso fue un espacio de producción e intercambio entre profesionales de diferentes áreas y líderes comunitarios, buscando siempre una mirada más amplia a las prácticas asistenciales, al apoyo psicosocial y de valoración de las formas de atención a la salud utilizadas por las comunidades.

Tonic Immobility is Associated with PTSD Symptoms in Traumatized Adolescents.

PURPOSE: Growing evidence suggests that peritraumatic tonic immobility, an involuntary defensive response that involves extreme physical immobility and the perceived inability to escape, is a significant predictor of post-traumatic stress disorder (PTSD) symptomatology. However, this issue has not been specifically addressed in adolescents. Here, we investigated whether tonic immobility response experienced during the worst childhood or adolescent trauma is associated with PTSD symptom severity in a non-clinical student sample. METHODS: The sample was composed of students in 9th grade who were attending public and private schools. Symptoms of post-traumatic stress and tonic immobility were assessed using questionnaires. We performed bivariate and multivariate negative binomial regressions to examine whether tonic immobility was associated with PTSD symptomatology after controlling for confounders (peritraumatic dissociation, peritraumatic panic reactions, gender, age and time since trauma). RESULTS: We found an association between tonic immobility and PTSD symptom severity, even after controlling for confounders. Therefore, tonic immobility is associated with PTSD symptoms in trauma-exposed adolescents. CONCLUSION: These findings highlight tonic immobility as a possible risk factor that could be used to provide direction for more targeted trauma interventions for individuals, particularly those at risk for developing PTSD. Therefore, it contributes to preventing and reducing the psychiatric burden in adolescence and later in life.

Posttraumatic stress disorder among adolescents in Brazil: a cross-sectional study.

BACKGROUND: The frequency of trauma and different types of violence exposure in urban areas and their effects on the mental health of adolescents in developing countries are poorly investigated. Most information about traumatized young people comes from war scenarios or disasters. This study aimed to determine the prevalence of PTSD in trauma-exposed students in a low-resource city of the state of Rio de Janeiro, Brazil. The effects of sociodemographic and individual and family factors in the development of PTSD were also investigated. METHODS: Through multi-stage cluster sampling, 862 adolescents (Mage = 15 years old, 65% female) from public and private schools in the city of São Gonçalo were selected for the study. Self-rating structured questionnaires were applied to assess sociodemographic profile, exposure to physical and psychological violence (family, school, community), sexual abuse, social support, social functional impairment, resilience, and posttraumatic stress disorder. The data were grouped in blocks regarding sociodemographic, individual, family, and community variables. For statistical analysis, chi-square, Fisher's exact test, and logistic regression were performed. RESULTS: The PTSD prevalence was 7.8% among adolescents. Boys were exposed to significantly higher number of events of community violence, while girls to family violence. The adjusted odds ratio (OR) for PTSD were statistically significant for age (OR, 1.45, [95% CI, 1.043-2.007]), social functional impairment (OR, 4.82, [95% CI, 1.77-13.10]), severe maternal physical violence (OR, 2.79, [95% CI, 0.79-9.93]), psychological violence by significant people (OR, 3.96, [95% CI, 1.89-8.31]) and a high number of episodes of community violence (OR, 3.52, [95% CI, 1.47-8.40). CONCLUSIONS: There was a high prevalence of PTSD within this population associated with exposure to violence. Not only physical, but also psychological violence contributed to PTSD. The results also raise awareness to the differences in life trajectories between boys and girls regarding violence. These differences need to be better understood in order to enable the development of effective preventative interventions. Treating and preventing mental health disorders presents a challenge for countries, especially those with a lower degree of social and economic development and high community violence.

Narrative Exposure Therapy versus treatment as usual in a sample of trauma survivors who live under ongoing threat of violence in Rio de Janeiro, Brazil: study protocol for a randomised controlled trial.

BACKGROUND: One in three individuals who live in Rio de Janeiro experience a traumatic event within a period of 12 months. In the favelas particularly, trauma exposure is ongoing. Psychological sequalae include posttraumatic stress disorder (PTSD), depression and other mental disorders. Trauma-focused therapy approaches have emerged as the treatment of choice when the dangerous events are over, but symptoms have remained for an extended time period. Ideally, the victim is in a safe context during treatment. However, frequently, survivors cannot escape from situations characterised by ongoing threat and traumatic stress. The aim of this study is to research the effectiveness of Narrative Exposure Therapy in a sample of PTSD patients living under these conditions. METHODS: Individuals fulfilling the criteria for PTSD and who live in conditions of ongoing community violence (i.e. in the favelas) in Rio de Janeiro will be randomly assigned to one of two treatments: Narrative Exposure Therapy (NET) or treatment as usual (TAU). Clinical endpoints will be primarily PTSD and secondarily symptoms of shutdown dissociation, depression, substance involvement  and functionality. DISCUSSION: Effective treatment for PTSD patients who live in unsafe conditions could substantially reduce suffering of individuals and their families in Brazil. Based on this result, the extent to which such interventions may be useful as a first step in tackling the consequences of violence on a global scale will be discussed. TRIAL REGISTRATION: Deutsches Register Klinischer Studien (German Clinical Trials Register) DRKS00017843 . Registered on September 24, 2019.

Adolescence in public health - revisiting 25 years of publications. / O tema da adolescência na saúde coletiva - revisitando 25 anos de publicações.

This study aims to develop scientific knowledge on adolescence in publications from 1996 to 2020 in Journal Ciência & Saúde Coletiva (C&SC). This integrative systematic review was based on a bibliographic survey in SciELO's database, with the string word search strategy "Adolesc $" in title, abstract, and keywords of works published in the C&SC between 1996 and 2020. The abstracts of 432 publications were analyzed by age group, gender, skin color, social stratum, sample, place, methodology, and risk and protective factors. The results show that most of the abstracts brought studies exclusively focused on the adolescent population, with a smaller volume on children or adults. Most of the samples were collected in schools, followed by health services. The topics addressed in the papers are related to adolescents' individual attributes, family attributes, peer relationships; social scope, health conditions and diseases, accidents and violence, and health services. There is a need for special attention to adolescents' health requiring reflections in national academic production, aiming at systemic and complex knowledge focused on adolescent health promotion aspects, following the existing national legislation and laws.

Busca-se compreender o desenvolvimento do conhecimento científico sobre a adolescência expresso em publicações dos anos de 1996 a 2020 da revista Revista Ciência & Saúde Coletiva (C&SC). O estudo de revisão sistemática integrativa foi feito a partir de levantamento bibliográfico no SciELO com a estratégia de busca: "Adolesc$" em título, resumo e palavras-chave nos artigos da C&SC publicados entre 1996 e 2020. Resumos de 432 publicações foram analisados segundo faixa etária, sexo/gênero, cor da pele, estrato social, amostra, local, metodologia e fatores de risco/proteção. Os resultados mostram que grande parte volta-se exclusivamente para a adolescência e em menor quantidade infância ou vida adulta. Grande parte dos estudos foi realizada com amostras de adolescentes nas escolas, seguida por serviços de saúde. Os temas abordados nas publicações são: atributos individuais dos adolescentes; atributos familiares; relações entre pares; abrangência social; condições de saúde e doenças; acidentes e violências; e atuação profissional e de serviços. Constata-se a necessidade de atenção especial para a saúde dos adolescentes, que precisa estar refletida na produção acadêmica nacional, visando o conhecimento sistêmico, complexo e que se volte para a promoção à saúde dos adolescentes, acompanhando as normativas e leis nacionais existentes.

National Emergency Training in Mental Health and Psychosocial Care at COVID-19: an experience report / Capacitação nacional emergencial em saúde mental e atenção psicossocial na COVID-19: um relato de experiência

In March 2020, the World Health Organization declared a pandemic, due to the rapid spread of the SARS-Cov-2 virus, triggering the global alert about the need for rapid expansion of the capacity for surveillance, prevention and implementation of assistance structures for the countries' health systems. In the day after the statement by the Brazilian Ministry of Health, that recognized community transmission in Brazil, a group of researchers was invited to gather scientific evidence and best practices for mental health and psychosocial care at COVID-19. 1,563 articles were selected that referred to mental health and / or psychosocial care in contexts of health emergencies. Researchers, teachers and volunteers from 25 institutions, recognized for their notorious knowledge, participated, totaling 117 volunteer professionals. It was decided to set up an online national course. Altogether 60,780 professionals joined the course in the first 30 days of enrollment. The online modeling, synchronous and asynchronous, enabled training during a period of social distance, and also allowed professionals from different states in the national territory to have access to updated information based on national and international research, seeking to guarantee the strengthening of actions within the scope health policies, and based on international protocols.

Em março/2020, a Organização Mundial da Saúde emitiu a declaração de pandemia, em decorrência da disseminação do vírus SARS-Cov-2, disparando o alerta mundial sobre a necessidade de rápida expansão da capacidade de vigilância, prevenção e implementação das estruturas de assistência dos sistemas de saúde dos países. No dia seguinte a declaração do Ministério da Saúde que reconheceu a transmissão comunitária no Brasil, um grupo de pesquisadores foi convidado a reunir evidências científicas e melhores práticas de SMAPS na COVID-19. Foram selecionados 1.563 artigos que se referiam à saúde mental e/ou atenção psicossocial em contextos de emergências sanitárias. Participaram pesquisadores, docentes e voluntários de 25 instituições reconhecidas pelo notório saber, totalizando um montante de 117 profissionais voluntários. Optou-se por conformar um curso nacional na modalidade de Educação a distância. Ao todo 60.780 profissionais ingressaram no curso nos primeiros 30 dias de inscrição. A modelagem online, síncrona e assíncrona, possibilitou a formação durante período de distanciamento social, e também permitiu que profissionais de todos os estados, e do Distrito Federal, pudessem ter acesso a informações atualizadas e baseadas em pesquisas nacionais e internacionais, buscando garantir o fortalecimento das ações no âmbito das políticas de saúde, e com base nos protocolos internacionais.

The experience with volunteer and collaborative work in mental health and psychosocial care during the COVID-19 pandemic. / A experiência do trabalho voluntário e colaborativo em saúde mental e atenção psicossocial na COVID-19.

Brazil is the country of the world with the second most COVID-19 cases and deaths, and the pandemic's impacts pose multiple challenges for mental health. This paper reports on experience with the emergency organization of the volunteer and collaborative Working Group (GT, in Portuguese) on mental health and psychosocial care aimed at producing rapid responses for health services in the context of COVID-19. The study involved the identification and systematization of current evidence in the scientific literature on mental health and psychosocial care in public health emergencies and pandemics, with the establishment of a network involving 117 researchers and 25 institutions, and the organization of themes for the elaboration of materials, referenced on the response phases in public health emergencies and pandemics. In less than 60 days, 18 technical documents were produced, ranging from services organization and management for different vulnerable groups. The materials became references in health institutions and services. A national course on mental health and psychosocial care in COVID-19 was also organized, with more than 60,000 people registered. The experience provides food for thought and a contribution for future experiences involving knowledge translation in the current pandemic and in future public health emergencies and pandemics, with the following: (1) combination of volunteer and collaborative work involving professionals with experience in the organization of services and care in past events; (2) reliance on institutional support and resources; (3) speed and credibility of work involving the establishment of networks of professionals and institutions; and (4) responses to the urgent needs with the capacity to shape paths for care in mental health and psychosocial care.

O Brasil é um dos países com maior número de casos e óbitos na pandemia por COVID-19, e seus impactos representam múltiplos desafios para a saúde mental. Esta comunicação relata a experiência de conformação emergencial do Grupo de Trabalho (GT) voluntário e colaborativo em saúde mental e atenção psicossocial, com objetivo de fornecer respostas rápidas aos serviços de saúde no contexto da COVID-19. O trabalho envolveu a identificação e sistematização de evidências atualizadas da literatura científica sobre saúde mental e atenção psicossocial em situações de emergências em saúde pública e pandemias, a constituição de uma rede envolvendo 117 pesquisadores e 25 instituições, além da organização de temas para elaboração de materiais, tendo como referência as fases de resposta em emergências em saúde pública e pandemias. Em menos de 60 dias foram publicados 18 documentos técnicos norteadores, englobando desde a organização e gestão dos serviços voltados aos diferentes grupos vulneráveis, ações que se tornaram referência em instituições e serviços de saúde, tendo sido também lançado um curso nacional sobre saúde mental e atenção psicossocial na COVID-19, com mais de 60 mil inscritos. Da experiência, são destacados tópicos para reflexão e contribuição para futuras ações, envolvendo translação do conhecimento nesta e em próximas emergências em saúde pública e pandemias: (1) combinar o trabalho voluntário e colaborativo com o envolvimento de profissionais experientes na organização de serviços e atenção em eventos passados; (2) contar com o suporte e recursos institucionais; (3) envolver a constituição de redes de profissionais e instituições para atingir rapidez e credibilidade no trabalho; (4) para as respostas às necessidades urgentes, deve-se envolver também a capacidade de moldar caminhos para a atenção e os cuidados em saúde mental e atenção psicossocial.

Brasil es uno de los países con mayor número de casos y óbitos en la pandemia por COVID-19 y sus impactos representan múltiples desafíos para la salud mental. Esta comunicación relata la experiencia de conformación de emergencia del Grupo de Trabajo (GT) voluntario y colaborativo en salud mental y atención psicosocial, con el objetivo de proporcionar respuestas rápidas a los servicios de salud en el contexto de la COVID-19. El trabajo implicó la identificación y sistematización de evidencias actualizadas de la literatura científica sobre salud mental y atención psicosocial en situaciones de emergencias en salud pública y pandemias, la constitución de una red implicando a 117 investigadores y 25 instituciones, la organización de temas para la elaboración de materiales, teniendo como referencia las fases de respuesta en emergencias en salud pública y pandemias. En menos de 60 días se publicaron 18 documentos técnicos orientativos, desde la organización de los servicios y gestión de los servicios a los diferentes grupos vulnerables, que se convirtieron en referencia en instituciones y servicios de salud, así como el lanzamiento de un curso nacional sobre salud mental y atención psicosocial en la COVID-19, con más de 60 mil inscritos. De la experiencia se destacan temas para reflexión y contribución para futuras experiencias, implicando translación del conocimiento en esta y en futuras emergencias en salud pública y pandemias: (1) combinar el trabajo voluntario y colaborativo con la implicación profesionales con experiencia en la organización de servicios y atención en eventos pasados; (2) contar con el apoyo y recursos institucionales; (3) la rapidez y la credibilidad del trabajo implica la constitución de redes de profesionales e instituciones; (4) las respuestas a las necesidades urgentes deben implicar también la capacidad de moldear caminos para la atención y los cuidados en salud mental y atención psicosocial.

Experiencing community and domestic violence is associated with epigenetic changes in DNA methylation of BDNF and CLPX in adolescents.

Experiencing violence changes behavior, shapes personalities, and poses a risk factor for mental disorders. This association might be mediated through epigenetic modifications that affect gene expression, such as DNA methylation. The present study investigated the impact of community and domestic violence on DNA methylation measured in saliva collected from 375 individuals including three generations: grandmothers (n = 126), mothers (n = 125), and adolescents (n = 124, 53% female). Using the Infinium HumanMethylation450 BeadChip array, in adolescents, we detected two CpG sites that showed an association of DNA methylation and lifetime exposure to community and domestic violence even after FDR correction: BDNF_cg06260077 (logFC -0.454, p = 3.71E-07), and CLPX_cg01908660 (logFC = -0.372, p = 1.38E-07). Differential DNA methylation of the CpG BDNF_cg06260077 associated with exposure to violence was also observed in the maternal but not the grandmaternal generation. BDNF (brain-derived neurotrophic factor) and CLPX (caseinolytic mitochondrial matrix peptidase chaperone subunit) genes are involved in neural development. Our results thus reveal altered molecular mechanisms of developmental and intergenerational trajectories in survivors of repeated violent experiences.

Capacitação nacional emergencial em Saúde Mental e Atenção Psicossocial na Covid-19: um relato de experiência / National emergency training in Mental Health and Psychosocial Care on Covid-19: an experience report

RESUMO Em março/2020, a Organização Mundial da Saúde emitiu a declaração de pandemia, em decorrência da disseminação do vírus SARS-CoV-2, disparando o alerta mundial sobre a necessidade de rápida expansão da capacidade de vigilância, prevenção e implementação das estruturas de assistência dos sistemas de saúde dos países. No dia seguinte à declaração do Ministério da Saúde que reconheceu a transmissão comunitária no Brasil, um grupo de pesquisadores foi convidado a reunir evidências científicas e melhores práticas de Saúde Mental e Atenção Psicossocial (SMAPS) na Covid-19. Foram selecionados 1.563 artigos que se referiam à saúde mental e/ou atenção psicossocial em contextos de emergências sanitárias. Participaram pesquisadores, docentes e voluntários de 25 instituições reconhecidas pelo notório saber, totalizando um montante de 117 profissionais voluntários. Optou-se por conformar um curso nacional na modalidade de Educação a Distância. Ao todo, 60.780 profissionais ingressaram no curso nos primeiros 30 dias de inscrição. A modelagem on-line, síncrona e assíncrona, possibilitou a formação durante o período de distanciamento social, assim como permitiu que profissionais de todos os estados, e do Distrito Federal, pudessem ter acesso a informações atualizadas e baseadas em pesquisas nacionais e internacionais, buscando garantir o fortalecimento das ações no âmbito das políticas de saúde, e com base nos protocolos internacionais.

ABSTRACT In March 2020, the World Health Organization declared a pandemic, due to the rapid spread of the SARS-CoV-2 virus, triggering a global alert about the need for rapid expansion of the capacity for surveillance, prevention and implementation of assistance structures for countries' health systems. On the day after the statement by the Brazilian Ministry of Health, that recognized community transmission in Brazil, a group of researchers was invited to gather scientific evidence and best practices for Mental Health and Psychosocial Care on Covid-19. A total of 1,563 articles were selected that referred to mental health and/or psychosocial care in contexts of health emergencies. Researchers, professors and volunteers from 25 institutions, recognized for their notorious knowledge, participated, totaling 117 volunteer professionals. It was decided to set up an online national course. Altogether, 60,780 professionals joined the course in the first 30 days of enrollment. The online modeling, synchronous and asynchronous, enabled training during a period of social distance, and also allowed professionals from different states in the national territory to have access to updated information based on national and international research, seeking to guarantee the strengthening of actions within the scope of health policies, and based on international protocols.

Capacitação nacional emergencial em saúde mental e atenção psicossocial na COVID-19: um relato de experiência / National emergency training in mental health and psychosocial care at COVID-19: an experience report

Em março/2020, a Organização Mundial da Saúde emitiu a declaração de pandemia, em decorrência da disseminação do vírus SARS-Cov-2, disparando o alerta mundial sobre a necessidade de rápida expansão da capacidade de vigilância, prevenção e implementação das estruturas de assistência dos sistemas de saúde dos países. No dia seguinte a declaração do Ministério da Saúde que reconheceu a transmissão comunitária no Brasil, um grupo de pesquisadores foi convidado a reunir evidências científicas e melhores práticas de SMAPS na COVID-19. Foram selecionados 1.563 artigos que se referiam à saúde mental e/ou atenção psicossocial em contextos de emergências sanitárias. Participaram pesquisadores, docentes e voluntários de 25 instituições reconhecidas pelo notório saber, totalizando um montante de 117 profissionais voluntários. Optou-se por conformar um curso nacional na modalidade de Educação a distância. Ao todo 60.780 profissionais ingressaram no curso nos primeiros 30 dias de inscrição. A modelagem online, síncrona e assíncrona, possibilitou a formação durante período de distanciamento social, e também permitiu que profissionais de todos os estados, e do Distrito Federal, pudessem ter acesso a informações atualizadas e baseadas em pesquisas nacionais e internacionais, buscando garantir o fortalecimento das ações no âmbito das políticas de saúde, e com base nos protocolos internacionais.

A experiência do trabalho voluntário e colaborativo em saúde mental e atenção psicossocial na COVID-19 / La experiencia del trabajo voluntario y colaborativo en salud mental y atención psicosocial en COVID-19 / The experience with volunteer and collaborative work in mental health and psychosocial care during the COVID-19 pandemic

O Brasil é um dos países com maior número de casos e óbitos na pandemia por COVID-19, e seus impactos representam múltiplos desafios para a saúde mental. Esta comunicação relata a experiência de conformação emergencial do Grupo de Trabalho (GT) voluntário e colaborativo em saúde mental e atenção psicossocial, com objetivo de fornecer respostas rápidas aos serviços de saúde no contexto da COVID-19. O trabalho envolveu a identificação e sistematização de evidências atualizadas da literatura científica sobre saúde mental e atenção psicossocial em situações de emergências em saúde pública e pandemias, a constituição de uma rede envolvendo 117 pesquisadores e 25 instituições, além da organização de temas para elaboração de materiais, tendo como referência as fases de resposta em emergências em saúde pública e pandemias. Em menos de 60 dias foram publicados 18 documentos técnicos norteadores, englobando desde a organização e gestão dos serviços voltados aos diferentes grupos vulneráveis, ações que se tornaram referência em instituições e serviços de saúde, tendo sido também lançado um curso nacional sobre saúde mental e atenção psicossocial na COVID-19, com mais de 60 mil inscritos. Da experiência, são destacados tópicos para reflexão e contribuição para futuras ações, envolvendo translação do conhecimento nesta e em próximas emergências em saúde pública e pandemias: (1) combinar o trabalho voluntário e colaborativo com o envolvimento de profissionais experientes na organização de serviços e atenção em eventos passados; (2) contar com o suporte e recursos institucionais; (3) envolver a constituição de redes de profissionais e instituições para atingir rapidez e credibilidade no trabalho; (4) para as respostas às necessidades urgentes, deve-se envolver também a capacidade de moldar caminhos para a atenção e os cuidados em saúde mental e atenção psicossocial.

Brasil es uno de los países con mayor número de casos y óbitos en la pandemia por COVID-19 y sus impactos representan múltiples desafíos para la salud mental. Esta comunicación relata la experiencia de conformación de emergencia del Grupo de Trabajo (GT) voluntario y colaborativo en salud mental y atención psicosocial, con el objetivo de proporcionar respuestas rápidas a los servicios de salud en el contexto de la COVID-19. El trabajo implicó la identificación y sistematización de evidencias actualizadas de la literatura científica sobre salud mental y atención psicosocial en situaciones de emergencias en salud pública y pandemias, la constitución de una red implicando a 117 investigadores y 25 instituciones, la organización de temas para la elaboración de materiales, teniendo como referencia las fases de respuesta en emergencias en salud pública y pandemias. En menos de 60 días se publicaron 18 documentos técnicos orientativos, desde la organización de los servicios y gestión de los servicios a los diferentes grupos vulnerables, que se convirtieron en referencia en instituciones y servicios de salud, así como el lanzamiento de un curso nacional sobre salud mental y atención psicosocial en la COVID-19, con más de 60 mil inscritos. De la experiencia se destacan temas para reflexión y contribución para futuras experiencias, implicando translación del conocimiento en esta y en futuras emergencias en salud pública y pandemias: (1) combinar el trabajo voluntario y colaborativo con la implicación profesionales con experiencia en la organización de servicios y atención en eventos pasados; (2) contar con el apoyo y recursos institucionales; (3) la rapidez y la credibilidad del trabajo implica la constitución de redes de profesionales e instituciones; (4) las respuestas a las necesidades urgentes deben implicar también la capacidad de moldear caminos para la atención y los cuidados en salud mental y atención psicosocial.

Brazil is the country of the world with the second most COVID-19 cases and deaths, and the pandemic's impacts pose multiple challenges for mental health. This paper reports on experience with the emergency organization of the volunteer and collaborative Working Group (GT, in Portuguese) on mental health and psychosocial care aimed at producing rapid responses for health services in the context of COVID-19. The study involved the identification and systematization of current evidence in the scientific literature on mental health and psychosocial care in public health emergencies and pandemics, with the establishment of a network involving 117 researchers and 25 institutions, and the organization of themes for the elaboration of materials, referenced on the response phases in public health emergencies and pandemics. In less than 60 days, 18 technical documents were produced, ranging from services organization and management for different vulnerable groups. The materials became references in health institutions and services. A national course on mental health and psychosocial care in COVID-19 was also organized, with more than 60,000 people registered. The experience provides food for thought and a contribution for future experiences involving knowledge translation in the current pandemic and in future public health emergencies and pandemics, with the following: (1) combination of volunteer and collaborative work involving professionals with experience in the organization of services and care in past events; (2) reliance on institutional support and resources; (3) speed and credibility of work involving the establishment of networks of professionals and institutions; and (4) responses to the urgent needs with the capacity to shape paths for care in mental health and psychosocial care.

Does Prenatal Stress Shape Postnatal Resilience? - An Epigenome-Wide Study on Violence and Mental Health in Humans.

Stress during pregnancy widely associates with epigenetic changes and psychiatric problems during childhood. Animal studies, however, show that under specific postnatal conditions prenatal stress may have other, less detrimental consequences for the offspring. Here, we studied mental health and epigenome-wide DNA methylation in saliva following intimate partner violence (IPV) during pregnancy in São Gonçalo, a Brazilian city with high levels of violence. Not surprisingly, mothers exposed to pregnancy IPV expressed elevated depression, PTSD and anxiety symptoms. Children had similar psychiatric problems when they experienced maternal IPV after being born. More surprisingly, when maternal IPV occurred both during (prenatal) and after pregnancy these problems were absent. Following prenatal IPV, genomic sites in genes encoding the glucocorticoid receptor (NR3C1) and its repressor FKBP51 (FKBP5) were among the most differentially methylated and indicated an enhanced ability to terminate hormonal stress responses in prenatally stressed children. These children also showed more DNA methylation in heterochromatin-like regions, which previously has been associated with stress/disease resilience. A similar relationship was seen in prenatally stressed middle-eastern refugees of the same age as the São Gonçalo children but exposed to postnatal war-related violence. While our study is limited in location and sample size, it provides novel insights on how prenatal stress may epigenetically shape resilience in humans, possibly through interactions with the postnatal environment. This translates animal findings and emphasizes the importance to account for population differences when studying how early life gene-environment interactions affects mental health.

Resiliência em contextos de violência: análise da literatura internacional publicada no ano de 2017 / Resilience in contexts of violence: A international analysis of the 2017 published literature

O objetivo norteador do capítulo é identificar quais os temas ou fatores que associam o estudo de ambos os construtos - violência e resiliência, e refletir sobre como está o desenvolvimento teórico e metodológico da temática na produção científica recente. (AU)

Aporte das neurociências para compreensão da violência / Contribution of the neurosciences for the comprehension of the violence

Este capítulo tem como objetivo analisar a produção científica de autores brasileiros sobre as relações entre agressão e violência no campo das neurociências, especialmente da neurobiologia, entre os anos de 2001 e 2013. A intenção é refletir sobre os significativos avanços na integração entre biologia e meio social,

Reorganização e ressurgência de relações equivalentes instruídas e modeladas por contingências: efeito da extinção / Reorganization and resurgence of instructed and modeled by contingencie equivalence relations: effect of extinction

A reorganização e a ressurgência de classes de estímulos equivalentes foram investigadas em dois experimentos. Foram manipuladas as condições de instrução e de exposição direta às contingências e o número de blocos de extinção. Do Experimento 1 (Exp1), participaram três universitários e do Experimento 2 (Exp2), dois grupos (G1_Exp2 e G2_Exp2), com oito estudantes em cada. O procedimento consistiu de: Treino Inicial; Treino Tardio (fase de reorganização das classes); blocos de extinção (4 no Exp1 e 8 no Exp2); teste de ressurgência. No Exp1 e para o G1_Exp2, as relações eram instruídas e para o G2_Exp2, elas eram modeladas por contingência. Todos os participantes do Exp1 e do G1_Exp2 formaram e reorganizaram as classes. Seis participantes do G2_Exp2 formaram e cinco reorganizaram as classes. O teste de ressurgência dos dois experimentos mostrou predomínio de respostas consistentes com o treino tardio. Conclui-se que foi demonstrada a reorganização das classes de equivalência, mas não a ressurgência delas.(AU)

The reorganization and the resurgence of stimulus equivalence classes were investigated in two experiments. The conditions of instructions and direct exposition to the contingencies, and the number of extinction blocks were manipulated. In Experiment 1 (Exp1) three undergraduate students participated in Experiment 2 (Exp2), two groups (G1_Exp2 and G2_Exp2) with eight students each. The procedure consisted of: Initial Training; Late Training (reorganization phase of the classes); extinction blocks (4 in Exp1 and 8 in the Exp2); resurgence test. In Exp1 and for G1_Exp2, the relations had been instructed and for G2_Exp2 they were modeled by contingency. All the participants of Exp1 and of G1_Exp2 formed and reorganized the equivalent classes. Six participants from G2_Exp2 formed equivalent classes and 5 reorganized the classes. The resurgence test of the two experiments showed prevalence of responding consistent with the late training. It was concluded that reorganization of the equivalent classes were demonstrated but not the resurgence of them.(AU)