Iliac nodal metastases from carcinoma of the penis treated surgically.

OBJECTIVE: To evaluate survival in patients with metastatic iliac nodal involvement from carcinoma of the penis. PATIENTS AND METHODS: Thirteen patients with metastases to the iliac nodes were selected from 68 with squamous cell carcinoma of the penis who had undergone amputation and bilateral ilio-inguinal lymphadenectomy. The 1978 Tumour-Nodes-Metastasis system was used for staging. Deep and superficial lymph nodes were removed during the inguinal procedure. Lymph nodes below the common iliac artery (external and obturator) were removed and histologically evaluated for the presence of metastases. RESULTS: The mean (median, range) follow-up was 55.5 (8. 8, 0.3-235) months, at the end of which five patients were free of cancer, seven had died from cancer or treatment-related complications and one was lost to follow-up. Four of the five survivors had metastases to only one iliac lymph node. CONCLUSION: Ilio-inguinal lymphadenectomy may have a significant role in increasing the survival of patients with metastases to only one iliac lymph node.

Immunotherapy of metastases with lymphocytes treated with exogenous RNA in mice bearing B16 melanoma.

Subline B16-F10, a variant cell line of B16 melanoma, is highly metastatic to the lung when injected intravenously into C57BL/6 mice. This experimental metastasis model was used to test the anti-tumor effect of exogenous RNA extracted from the lymphoid organs of immunized animals with B16-F10 cells. This RNA preparation is referred to as B16-RNA. Adoptive immunotherapy with lymphocytes treated with B16-RNA was effective in reducing significantly the number of pulmonary metastatic nodules. Lymphocytes incubated with medium alone or with RNA from non-immunized animals (N-RNA) were used as controls. The ability of B16-RNA in modulating antimetastatic activity of normal lymphocytes is abolished by hydrolysis with KOH. This finding indicates that the integrity of the polynucleotide chain is essential for the activity of B16-RNA. The anti-tumor effect of lymphocytes treated with B16-RNA was enhanced by incubation with a low dose of interleukin-2 (IL-2). A possible role of the double-stranded RNA dependent protein kinase in this phenomenon is discussed.

Quimio-radioterapia em carcinoma tipo "oat cell" do esôfago / Chemoradiotherapy in oat cell carcinoma of esophagus

É relatado um caso de um paciente com carcinoma indiferenciado de pequenas células originário no esôfago que foi tratado com quimio-radioterapia. Durante a quimioterapia de induçäo com Ciclofosfamida, Epirrubicina e Etoposide houve desaparecimento completo da neoplasia. A radioterapia foi utilizada para consolidaçäo da resposta. Dois anos e meio após diagnóstico o paciente foi a óbito após desenvolvimento de múltiplas metástases.