1.
Urologiia
; (2): 26-9, 2008.
Artigo
em Russo
| MEDLINE
| ID: mdl-18572765
RESUMO
The study of polymorphic variants of GSTT1, GSTM1 and GSTP1 genes from 61 patients with prostatic cancer (PC) has shown that incidence of 0/0 genotype GSTT1 and GSTM1 in PC patients was significantly higher of that in healthy men (n = 100) (34.4 and 15% in p = 0.007 and 60.7 and 43% in p = 0.04, respectively). PC risk in carriers of a GSTT1 deletion form was 2.97, CI95%--1.3-6.84, GSTM1--2.04 in CI95% 1.02-4.1. The analysis of combinations of pathological genotypes of xenobiotic biotransformation enzymes has demonstrated that 89.8% PC patients have a mutation in one of the genes GSTT1, GSTM1 or GSTP1.
Assuntos
Glutationa S-Transferase pi/genética , Glutationa Transferase/genética , Mutação , Proteínas de Neoplasias/genética , Polimorfismo Genético , Neoplasias da Próstata/genética , Idoso , Idoso de 80 Anos ou mais , Genótipo , Glutationa S-Transferase pi/metabolismo , Glutationa Transferase/metabolismo , Humanos , Masculino , Pessoa de Meia-Idade , Proteínas de Neoplasias/metabolismo , Neoplasias da Próstata/enzimologia
2.
Vopr Pitan
; (2): 70, 1982.
Artigo
em Russo
| MEDLINE
| ID: mdl-6283738
