RESUMO
In this study a 2(2) factorial design has been applied to the evaluation of dissolution characteristics of phenylpropranolamine hydrochloride (PPA.HCl) from tableted microcapsules. The kinetic model according to the Rosin-Rimmler-Sperling-Bennet-Weillbull (RRSBW) distribution was applied for the parametric representation of the dissolution curves. The effect of two factors; drug particle size and kind of disintegrating agent, on the dissolution rate of PPA.HCl were studied at two levels. The factorial design method proved to be useful for the examination of tableted microcapsules.
Assuntos
Fenilpropanolamina/administração & dosagem , Cápsulas , Preparações de Ação Retardada , Composição de Medicamentos , Excipientes , Cinética , Modelos Químicos , Tamanho da Partícula , Fenilpropanolamina/química , Solubilidade , ComprimidosRESUMO
Microcapsules of phenylpropanolamine hydrochloride with core:wall ratios of 1:1, 2:1 and 1:2 were prepared by the coacervation-phase separation method, using ethylcellulose as the coating material. Two batches of PPA.HCl powder with different particle sizes (> 58 microns and < 28 microns) were used as the core material. The different sizes of microcapsules were separated using a range of standard sieves (840-247 microns). The effects of drug particle size, the media pH and the core:wall ratio on the dissolution kinetics were studied, and evaluated kinetically.
Assuntos
Fenilpropanolamina/administração & dosagem , Fenilpropanolamina/química , Cápsulas , Celulose/análogos & derivados , Química Farmacêutica , Preparações de Ação Retardada , Composição de Medicamentos , Gelatina , Concentração de Íons de Hidrogênio , Cinética , Tamanho da Partícula , SolubilidadeRESUMO
This work was planned to prepare sustained-action preparations of phenylpropanolamine hydrochloride by microencapsulation and by tableted microcapsules. Dissolution from both suspended microcapsules and the tablets was studied using the USP XXII basket method in simulated gastric and intestinal fluid without enzyme. The results were applied to zero-order, first-order, Hixson Crowell, RRSBW, Q/square root of t, (Bt)a and Higuchi kinetic models. Dissolution of PPA.HCl was found to be governed by the core:wall ratio, drug particle size, media pH and type of disintegrating agent. Dissolution kinetics were studied and evaluated.