1.
Anticancer Drug Des
; 11(3): 243-52, 1996 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-8663911
RESUMO
Some coumarin-, flavonol- and flavanon-acetic acids are described. The cytotoxicity of the synthesized compounds was determined on a human colon carcinoma cell line (LoVo) through evaluation of neutral red uptake, performed by the Riddel method. All tested derivatives were able to induce a statistically significant reduction of lysosomal neutral red uptake at 5 x 10(-5) M concentration. Some compounds were more active than the reference compound flavon-8-acetic acid.