Clinical nursing application of parenteral nutrition combined with enteral nutrition support in neurosurgery.

Background: To explore the clinical nursing effect of parenteral nutrition combined with enteral nutrition support in neurosurgery. Methodology: 200 neurosurgical patients were randomly divided into two groups. The time of parenteral nutrition combined with enteral nutrition support in our hospital (January 2021) was used as the cut-off point, the PN group and the PN+EN group were divided according to the cut-off point. Nutritional status, immune status, occurrence of adverse events, prognosis-related indicators were compared between the two groups. Results: Nutritional status and immune status at 7 days of nutritional support in the PN+EN group were higher than those in the PN group, The difference was statistically significant. The total incidence of adverse events in the PN+EN group (3.00%) was significantly lower than that in the PN group (11.00%), and the difference was statistically significant. The average ICU treatment time, average hospital stay and emerging infection rate in the PN+EN group were lower than those in the PN group, and the differences were statistically significant (P < 0.05). Conclusion: Parenteral nutrition combined with enteral nutrition support in neurosurgery can achieve a more ideal intervention effect. It is beneficial to the prognosis of patients and has a certain value of promotion and application.

Experimental study on soil fire temperature field of harvested site of Larix olgensis plantation.

We established a fire simulation experiment in the harvested site of Larix olgensis plantation and recorded the temperature of each test point at 500, 1000 and 1500 s during the fire by thermocouple temperature measurement. The data were displayed in the form of images to show soil temperature field at each layer during the fire. The results showed that when the wind speed was less than or equal to 2 m·s-1 or greater than or equal to 10 m·s-1, combustibles could not be fully burned. In the case of full combustion of combustibles, soil temperature at each layer was the highe-st when the wind speed was 6 m·s-1, with the affected soil depth being up to 12 cm or more. The maximum temperature at soil layer of 3 cm could reach 300 ℃. Compared with that at the non-cut stump, soil at the stump had a higher maximum temperature during the fire, with the soil temperature being higher near the stump. When the wind speed was 6 m·s-1, the temperature range at soil layer of 3 cm from the farthest and the nearest to the stump was from 198 ℃ to 315 ℃. With the deepening of soil layer, soil temperature sharply decreased. The temperature at the soil layer of 15 cm was almost unchanged during the fire test. The temperature at the soil layer of 12 cm was increased only when the wind speed was 6 m·s-1, and the temperature at the soil layer of 3 cm was the highest. When the wind speed was 6 m·s-1, the influence of fire on the soil temperature was the greatest, and soil at stump had the severest damage.

Anti-inflammatory effects of physalin E from Physalis angulata on lipopolysaccharide-stimulated RAW 264.7 cells through inhibition of NF-κB pathway.

Physalin E is a naturally occurring seco-steroid isolated from the stems and aerial parts of Physalis angulata L. (Solanaceae). This study was aimed to explore the anti-inflammatory effects of physalin E on RAW 264.7 mouse macrophages stimulated by lipopolysaccharide (LPS) and the potential underlying mechanisms. The results showed that physalin E significantly inhibited LPS-induced tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) expression and secretion in a dose-dependent manner. Unlike dexamethasone, these effects could not be blocked by miferstone (RU486). Meanwhile, physalin E reduced the degradation of I-kappa B protein in the cytoplasm and downregulated the nuclear factor-κB (NF-κB) p65 protein in the nuclear, which resulted in the inhibition of the NF-κB nuclear translocation. In conclusion, physalin E exerts its anti-inflammatory activities in LPS-induced macrophages. Physalin E can inhibit the production of inflammatory cytokines by targeting the NF-κB signaling pathway.