1.
Org Lett
; 25(2): 320-324, 2023 Jan 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36594742
RESUMO
A catalytic, direct synthetic strategy for preparing ynehydrazides with terminal alkynes and dialkyl azodicarboxylates is described. The protocol utilizes a cheap copper catalyst in combination with a catalytic amount of a weak base. The high sustainability, good practicality, broad substrate scope, and wide functional group tolerance comprised the advantages of this reaction. Synthetic applications and preliminary mechanistic studies have been conducted.