RESUMO
We assessed the long-term immunity to hepatitis B among 242 Egyptian children aged 6-12 years who had received a full vaccination course in infancy, and investigated the factors associated with immunity. Only 39.4% of the children had protective (> or = 10 lU/L) hepatitis B surface antibody levels (HBsAb). This proportion decreased with age but the decrease was not statistically significant. The mean level of HBsAb decreased significantly with increasing age (P = 0.026). A significant negative correlation was found between current age and HBsAb levels (r = -0.31, P = 0.041). Age and weight-for-age were found to be significant predictors of non-protective HBsAb levels.
Assuntos
Anticorpos Anti-Hepatite B/sangue , Vacinas contra Hepatite B/imunologia , Vacinação , Fatores Etários , Peso Corporal , Criança , Estudos Transversais , Egito , Feminino , Necessidades e Demandas de Serviços de Saúde , Antígenos de Superfície da Hepatite B/imunologia , Humanos , Imunidade Ativa , Esquemas de Imunização , Imunização Secundária , Modelos Logísticos , Masculino , Análise Multivariada , Programas Nacionais de Saúde , Fatores de Risco , Estudos Soroepidemiológicos , Fatores Socioeconômicos , Inquéritos e Questionários , Saúde da População Urbana/estatística & dados numéricos , Vacinação/métodosRESUMO
To determine seroprevalence of anti-hepatitis A virus (HAV) antibodies and potential risk factors for and age of contracting symptomatic hepatitis A infection among children of different socioeconomic status (SES) in Cairo, we carried out a cross-sectional study on 426 children aged 3-18 years from low SES areas and 142 from high SES areas. Seroprevalence was significantly higher with age. Seropositivity to anti-HAV antibodies was significantly higher among children of low and very low SES, 90%, compared to children of high SES, 50%. Water supply and sewage disposal were the most significant risk factors for HAV seropositivity in children of low SES. Children of high SES were more likely to be vulnerable to infection in adolescence than those of low SES.
Assuntos
Proteção da Criança/estatística & dados numéricos , Hepatite A/epidemiologia , Classe Social , Saúde da População Urbana/estatística & dados numéricos , Adolescente , Distribuição por Idade , Alanina Transaminase/sangue , Criança , Pré-Escolar , Estudos Transversais , Egito/epidemiologia , Doenças Endêmicas/estatística & dados numéricos , Feminino , Hepatite A/imunologia , Hepatite A/metabolismo , Anticorpos Anti-Hepatite A/sangue , Vírus da Hepatite A Humana/imunologia , Humanos , Masculino , Vigilância da População , Eliminação de Resíduos/estatística & dados numéricos , Características de Residência/estatística & dados numéricos , Fatores de Risco , Estudos Soroepidemiológicos , Distribuição por Sexo , Fatores Socioeconômicos , Abastecimento de Água/estatística & dados numéricosRESUMO
To determine seroprevalence of anti-hepatitis A virus [HAV] antibodies and potential risk factors for and age of contracting symptomatic hepatitis A infection among children of different socioeconomic status [SES] in Cairo, we carried out a cross-sectional study on 426 children aged 3-18 years from low SES areas and 142 from high SES areas. Seroprevalence was significantly higher with age. Seropositivity to anti-HAV antibodies was significantly higher among children of low and very low SES, 90%, compared to children of high SES, 50%. Water supply and sewage disposal were the most significant risk factors for HAV seropositivity in children of low SES. Children of high SES were more likely to be vulnerable to infection in adolescence than those of low SES
Assuntos
Hepatite A , Vírus da Hepatite A Humana , Proteção da Criança , Fatores de Risco , Saúde da População Urbana , Classe Social , Abastecimento de Água , Distribuição por Idade , Distribuição por Sexo , Estudos Soroepidemiológicos , Fatores SocioeconômicosRESUMO
We assessed the long-term immunity to hepatitis B among 242 Egyptian children aged 6-12 years who had received a full vaccination course in infancy, and investigated the factors associated with immunity. Only 39.4% of the children had protective [>/= 10 IU/L] hepatitis B surface antibody levels [HBsAb]. This proportion decreased with age but the decrease was not statistically significant. The mean level of HBsAb decreased significantly with increasing age [P = 0.026]. A significant negative correlation was found between current age and HBsAb levels [r = -0.31, P = 0.041]. Age and weight-for-age were found to be significant predictors of non-protective HBsAb levels
