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1.
Nephrourol Mon ; 6(6): e22112, 2014 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-25738114

RESUMO

BACKGROUND: Cardiovascular biomarkers such as N-terminal pro-B-type natriuretic peptide (NT-proBNP), cardiac troponin T (cTnT), hs-CRP (high sensitivity C-reactive protein), and albuminuria predict underlying heart disease in the general population as well as CKD patients. OBJECTIVES: We aimed to study the association of NT-proBNP, cTnT, hs-CRP, and spot urine albumin creatinine ratio with carotid intima media thickness (CIMT) for cardiovascular risk estimation in predialysis CKD (chronic kidney disease) patients. PATIENTS AND METHODS: This cross-sectional study included a total of 120 adult predialysis CKD patients. Forty patients were allocated in each predialysis CKD group of stages 3, 4, and 5. Serum cTnT and hs-CRP, plasma NT-proBNP, and single spot urine albumin creatinine ratio (ACR) were measured. Ultrasonographic examination of carotid artery was done with 7.5 MHz linear probe in B mode ultrasonography and carotid intima media thickness was measured. RESULTS: Mean values ± standard deviation of plasma NT-proBNP (pg/mL), serum hs-CRP (mg/L), spot urine ACR (mg/g of creatinine), and CIMT (mm) were 585.68 ± 514.84, 5.96 ± 2.52, 719.37 ± 411.36, and 0.78 ± 0.15, respectively in predialysis CKD patients (n = 120). Serum cTnT level was high in 40% of predialysis CKD patients. Among cardiovascular biomarkers, plasma NT-proBNP had maximum strength of correlation (Spearman Rho correlation coefficient; r = 0.575 and P < 0.0001) with the carotid intima media thickness followed by serum cTnT (Spearman Rho correlation coefficient; r = 0.419 and P < 0.0001), spot urine albumin creatinine ratio (Spearman Rho correlation coefficient; r = 0.322 and P < 0.0001), and serum hs-CRP (Spearman Rho correlation coefficient; r = 0.246 and P = 0.007). CONCLUSIONS: Nontraditional cardiovascular biomarkers such as plasma NT-proBNP, serum cTnT, serum hs-CRP, and spot urine ACR significantly correlate with CIMT. These biomarkers can estimate the cardiovascular risk in a predialysis CKD population with expected high cardiac morbidity and mortality.

2.
Acta Orthop Belg ; 73(4): 541-3, 2007 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-17939490

RESUMO

Giant cell tumour (GCT) of the anterior arc of a rib is a very rare occurrence and quite often the diagnosis is delayed. We report a case of GCT of a rib arising from the anterior arc which presented as a breast lump. The diagnosis of GCT was considered in the differentials only when percutaneous biopsy revealed multinucleated osteocleastic giant cells. Further diagnosis was confirmed by spotted oblique radiographs and computed tomography (CT). Surgical excision with repair of the chest wall by a mesh was done. The postoperative histopathological examination of the resected specimen confirmed the preoperative diagnosis of giant cell tumour. The present article aims to aware the reader about such rare presentations of GCT, which should be included in the differential diagnosis of a tumour originating from the anterior arc of the rib.


Assuntos
Neoplasias Ósseas/diagnóstico , Neoplasias da Mama/diagnóstico , Tumores de Células Gigantes/diagnóstico , Costelas , Adulto , Diagnóstico Diferencial , Feminino , Humanos
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