[Effect of somatotropin on the course and result of combined radiation and mechanical injury]. / Vliianie somatotropina na techenie i iskhody kombinirovannogo radiatsionno-mekhanicheskogo porazheniia.

In the experiment on rats it was shown that injection of somatotropin (1 ED/kg, i.m. at 1, 3, 5, 7 and 9 days) after combined irradiation and mechanical injury (4.5 Gy, LD50/30 and plural fractures) improved the overall condition of the rats and increased the survival. The drug accelerated the bone regeneration.

[Neuromediator mechanisms of the effect of the antihistamine agent dimebone on the brain]. / Neiromediatornye mekhanizmy deistviia antigistaminnogo preparata dimebona na mozg.

Dimebone was shown to inhibit monoamine oxidase (MAO) deaminating dopamine and serotonin, decrease dopamine metabolism in the basal ganglia of the rat brain, increase noradrenaline level and depress dopamine deamination in the hypothalamus. Dimebone first increased and then diminished the release of dopamine in the cortex, with the concomitant MAO activation and the increase in dopamine and noradrenaline levels. The in vitro experiments have demonstrated that dimebone (10(-4)) preferentially inhibited MAO activity, type B and dopamine deamination in homogenates of different rat brain structures. The role of MAO inhibition in the mechanism of dimebone action on the catecholamine metabolism in the brain structures and its stimulating effect on CNS are discussed.

[Effect of the acetyl derivatives of 4,5,6,7-tetrahydroindole on the enterochromaffin cells and mediator metabolism of the rat brain]. / Vliianie atsetil'nykh proivzodnykh 4,5,6,7-tetragidroindola na énterokhromaffinnye kletke i mediatornyi obmen mozga krys.

It was reported previously that the analogues of dimecabin (1,2-dimethyl-3-carbethoxy-5-oxyindole),2-methyl-3-carbethoxy-5-oxyindole and the derivatives of 2-methyl-3-carbethoxy-4, 5, 6, 7-tetrahydroindole substituted in the 1st position reduce the content of argentaffinic substance in enterochromaffin cells (EC) for a long period of time. It has been shown that "recognizability" of the acetyl derivatives of 4, 5, 6, 7-tetrahydroindole by the EC receptor systems is preserved. Administration of the acetyl derivatives into the stomach (10 mg/kg for 5 days) induce a prolonged decrease in the argentaffin substance content in EC, and augment the noradrenaline level without exerting a pronounced effect on the dopamine content. These substances also inhibit monoamine oxidase and acetylcholinesterase activity in the rat brain. Detection in EC of the biologically active substances common to the APUD-system and the brain suggests a new trend in the study into the action mode of indole compounds.