1.
Pharmazie
; 34(12): 805-6, 1979 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-397494
RESUMO
Condensation of 2-methyl-6-nitro-4-quinazolone with different aldehydes was achieved by fusing the reactants in the presence of zinc chloride, affording 2-substituted styryl-6-nitro-4-quinazolones. 2-(3-substituted aminomethyl)-4-hydroxystyryl-6-nitro-4-quinazolones were also prepared through the Mannich reaction. The antimicrobial testing of five of the compounds prepared showed that some of them produce promising effects.
Assuntos
Anti-Infecciosos/síntese química , Quinazolinas/síntese química , Antibacterianos , Bactérias/efeitos dos fármacos , Candida albicans/efeitos dos fármacos , Testes de Sensibilidade Microbiana , Quinazolinas/farmacologia
2.
J Pharm Sci
; 66(11): 1623-5, 1977 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-915742
RESUMO
8-Monosubstituted and 5,8-disubstituted psoralen derivatives were prepared, and their skin-photosensitizing activity was evaluated. The results were correlated in terms of molecular configuration, and 8-allyloxypsoralen can be considered was a new agent of potent photodynamic activity.
Assuntos
Cumarínicos/síntese química , Ficusina/síntese química , Luz , Pele/efeitos da radiação , Adjuvantes Farmacêuticos/síntese química , Animais , Ficusina/farmacologia , Furocumarinas , Cobaias , Pele/efeitos dos fármacos , Relação Estrutura-Atividade
3.
Pharmazie
; 32(4): 240, 1977 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-896915
