Neurophysiological indices of language impairment in children.

Recent investigations of children with specific language impairment (SLI) have found deviant anatomical asymmetry of the perisylvian cortex. These studies argue that this deviant anatomical asymmetry is linked to the language disorders of SLI children. To date no studies have examined whether deviant functional asymmetry underlies the processing of spoken language in these children. In the current study, brain-electrical activity was recorded from 31 scalp sites while children with SLI listened to auditorally presented stories and two different nonsense contexts. Electrical activity was time-locked to the grammatical word "the" in these contexts. The SLI children showed reversed asymmetry compared to control children from 200 ms to 400 ms in processing "the" in all contexts. More specifically, they showed depressed processing at the left temporal scalp site (T7) and enhanced processing at the right temporal site (T8). The second spatial derivative (the Laplacian) of the voltage activity was calculated to remove constant voltage potential and uniform changes in voltage potential across the scalp. The Laplacian analysis indicated that the sources of the positive electrical activity seen at the temporal electrode sites T7 and T8 are the lateral surfaces of the temporal cortices. A comparison of the scalp topography of the voltage potentials and Laplacian also suggests that children with SLI lack some contribution from a deep neural generator, possibly in the hippocampus or basal ganglia. This investigation is the first to demonstrate a direct link between deviant neurophysiological asymmetry and the processing of spoken language in children with SLI.

Deviant neurophysiological asymmetry in children with language impairment.

Deviant anatomical asymmetry of perisylvian cortex is argued to be linked to specific language impairment (SLI). However, no studies have examined whether deviant functional asymmetry underlies the processing of spoken language. In the current study, brain-electrical activity was recorded from 31 scalp sites to the function word 'the' embedded in auditorally presented stories and nonsense contexts. The SLI children showed reversed asymmetry at electrode sites over temporal cortex compared to control children in processing this word in all contexts. They also appear to lack some contribution from a deep neural generator in processing 'the' in the story. This investigation is the first to demonstrate a direct link between deviant neurophysiological asymmetry and the processing of spoken language in children with SLI.

Maturation of mismatch negativity in school-age children.

OBJECTIVE: Event-related potentials were recorded to investigate the maturation of auditory processing in school-age children. DESIGN: The mismatch negativity (MMN) was obtained in an oddball tone discrimination paradigm in 66 school-age children and 12 adults. In the children's data, a prominent negativity to both the standard and deviant tone, peaking around 200 msec, was observed, and compared with the N1 auditory evoked potential component. RESULTS: The MMN was found to decrease with latency by 11 msec/yr from 4 to 10 yr of age. No developmental change in MMN amplitude was seen from 4 to 10 yr of age. However, the MMN amplitude was significantly smaller in adults than in children. The prominent negativity in children was significantly later than the adult N1 component, and did not change in latency from 4 to 10 yr of age. This finding adds to a body of evidence suggesting that this prominent negativity and the adult N1 are not the same component. The magnitude of the prominent negativity in children decreased slightly with age. CONCLUSION: Changes in the timing of the brain discriminative response, MMN, suggest systematic maturational changes in auditory processing.

An electrophysiological study of infants' sensitivity to the sound patterns of English speech.

The study explores 10- to 11-month-old infants' sensitivity to the phonological characteristics of their native language. Event-related potentials (ERPs) were obtained for tones that were superimposed on two versions of a story: an Unmodified version containing normal English function morphemes, and a Modified version in which the prosodic and segmental properties of a subset of function morphemes were changed to make them atypical. The 11-month-olds exhibited significantly lower amplitude ERPs to the tones during the Modified story than to the Unmodified story, whereas the 10-month-olds showed no differences. These results suggest that the 11-month-olds discriminated the two versions of the story based on their representations of the phonological properties of English. Further, the tone-probe ERP method can successfully be used to study the development of speech perception in the pre-linguistic infant.