RESUMO
A 73-year-old man had diabetes mellitus, diarrhea, weight loss, and a rash of several years' duration. The rash, termed necrolytic migratory erythema, was the most characteristic feature and eventually suggested the diagnosis of a glucagon-secreting tumor of the pancreas. Diabetic ketoacidosis also developed in our patient, a previously unrecognized occurrence with this syndrome.
Assuntos
Adenoma de Células das Ilhotas Pancreáticas/diagnóstico , Glucagon/metabolismo , Neoplasias Pancreáticas/diagnóstico , Síndromes Endócrinas Paraneoplásicas/diagnóstico , Adenoma de Células das Ilhotas Pancreáticas/metabolismo , Idoso , Diabetes Mellitus/etiologia , Eritema/etiologia , Humanos , Neoplasias Hepáticas , Masculino , Metástase Neoplásica , Neoplasias Pancreáticas/metabolismoRESUMO
PIP: A case of a rare association between pregnancy and the development of Cushing's syndrome is discussed. A 29-year-old woman developed Cushing's syndrome, characterized by hypokalemia, a high level of urinary 17-hydroxycorticoids not suppressed by dexamethasone therapy, a high level of plasma 11-hydroxycorticoids which did not show diurnal variation and failed to show suppression after dexamethasone therapy, and a high level of urinary 17-ketosteroids, within 12 weeks of her first pregnancy. Clinical and biochemical abnormalities disappeared rapidly after dilatation and curettage. No evidence of an ectopic ACTH-producing tumor or an adrenal cortical tumor was found. Abnormalities did not reappear with administration of HCG or with sequential estrogen-progestogen treatment.^ieng
