Preference for infant-directed speech in preterm infants.

The current study explores the effects of exposure to maternal voice on infant sucking in preterm infants. Twenty-four preterm infants averaging 35 weeks gestational age were divided randomly into two groups. A contingency between high-amplitude sucking and presentation of maternal voice was instituted for one group while the other group served as a yoked control. No significant differences were observed in sucking of the two groups, but the degree of pitch modulation of the maternal voice predicted an increase in the rate of infant sucking.

Necrotizing enterocolitis and the role of anemia of prematurity.

Necrotizing enterocolitis (NEC) is one of the most common surgical diseases of preterm infants, with significant short- and long-term morbidity and mortality. Although the etiology of NEC remains elusive, multiple factors adversely affecting the intestinal mucosal integrity of preterm infants are known to be associated with NEC. Anemia and red blood cell (RBC) transfusion-related gut injury have been shown to have strong correlation with NEC. Anemia potentially compromises mucosal integrity with subsequent poor healing, and this injury may be augmented by yet unknown factors associated with RBC transfusions. Although convincing evidence is lacking, there is a need for guidelines to keep the hematocrit within clinically and physiologically relevant limits by appropriate interventions. Further investigations need to focus on assessing the interplay between anemia, chronically hypoxemic/hypoperfused intestines, and early iron therapy or other pharmacologic approaches for prevention/treatment of anemia and RBC transfusions.