Hemodynamic Study of Cerebral Arteriovenous Malformation: Newtonian and Non-Newtonian Blood Flow.

OBJECTIVE: Arteriovenous malformation is a disease of the vascular system that occurs mainly in the cerebral arteries and spine. Numerical simulation as a powerful method is used to investigate the Cerebral Arteriovenous Malformation hemodynamic after occlusion of the abnormality step by step by embolization. METHODS: The computed tomography (CT) Angiographic imaging data of 2 patients are used and a geometric model is extracted by the Mimics software. Numerical simulation of blood flow is performed in both Newtonian and non-Newtonian models. The Navier-Stokes and continuity governing equations are solved by a finite element method using the COMSOL Multiphysics software (the commercial computational fluid dynamics (CFD) simulation software). To validate the numerical results, the real data on blood flow rate in the feeding artery and draining veins are used, as well as angiographic images at different times. RESULTS: Regarding the comparison of pressure contours for different occlusions of 0, 30, 50, and 90%, by increasing the amount of occlusion in the nidus, there is an increase in the blood pressure. Regarding the comparison of the blood flow velocity in the feeding artery, draining veins, and inside the AVM nidus for Newtonian and non-Newtonian models, there is a significant difference between these 2 simulations in vessels with smaller dimensions (such as vessels inside the nidus). CONCLUSIONS: By increasing the amount of nidus occlusion, the blood pressure is increased, so the blood supply process is better. According to a significant difference between the Newtonian and non-Newtonian simulations in vessels with smaller dimensions (such as vessels inside the nidus), therefore, non-Newtonian simulation should be done for different occlusions of 30, 50, and 90%.

Multiphysics Analysis of Ultrasonic Shock Wave Lithotripsy and Side Effects on Surrounding Tissues.

BACKGROUND: Today, the most common method for kidney stone therapy is extracorporeal shock wave lithotripsy. Current research is a numerical simulation of kidney stone fragmentation via ultrasonic shock waves. Most numerical studies in lithotripsy have been carried out using the elasticity or energy method and neglected the dissipation phenomenon. In the current study, it is solved by not only the linear acoustics equation, but also the Westervelt acoustics equation which nonlinearity and dissipation are involved. OBJECTIVE: This study is to compare two methods for simulation of shock wave lithotripsy, clarifying the effect of shock wave profiles and stones' material, and investigating side effects on surrounding tissues. MATERIAL AND METHODS: Computational study is done using COMSOL Multiphysics, commercial software based on the finite element method. Nonlinear governing equations of acoustics, elasticity and bioheat-transfer are coupled and solved. RESULTS: A decrease in the rise time of shock wave leads to increase the produced acoustic pressure and enlarge focus region. The shock wave damages kidney tissues in both linear and nonlinear simulation but the damage due to high temperature is very negligible compared to the High Intensity Focused Ultrasound (HIFU). CONCLUSION: Disaffiliation of wave nonlinearity causes a high incompatibility with reality. Stone's material is an important factor, affecting the fragmentation.

Quantitative assessment of parallel acoustofluidic device.

The advantage of ultrasonic fields in harmless and label-free applications intrigued researchers to develop this technology. The capability of acoustofluidic technology for medical applications has not been thoroughly analyzed and visualized. Toward efficient design, in this research, flowing fluid in a microchannel excited by acoustic waves is fully investigated. To study the behavior of acoustic streaming, the main interfering parameters such as inlet velocity, working frequency, displacement amplitude, fluid buffer material, and hybrid effect in a rectangular water-filled microchannel actuated by standing surface acoustic waves are studied. Governing equations for acoustic field and laminar flow are derived employing perturbation theory. For each set of equations, appropriate boundary conditions are applied. Results demonstrate a parallel device is capable of increasing the inlet flow for rapid operations. Frequency increment raises the acoustic streaming velocity magnitude. Displacement amplitude amplification increases the acoustic streaming velocity and helps the streaming flow dominate over the incoming flow. The qualitative analysis of the hybrid effect shows using hard walls can significantly increase the streaming power without depleting excessive energy. A combination of several effective parameters provides an energy-efficient and fully controllable device for biomedical applications such as fluid mixing and cell lysis.