RESUMO
Oral administration of 20, 40, 60, mg of dry Azadirachta indica leaf powder for 24 days resulted in decrease in the weights of seminal vesicles and ventral prostate, reduction in epithelial height, nuclear diameter and the secretory material in the lumen. Biochemically, there was a decrease in total protein, acid phosphatase activities. Seminal vesicles and ventral prostate being androgen dependent, the regressive changes histologically as well as biochemically, suggests the antiandrogenic property of the neem leaves.
Assuntos
Folhas de Planta/química , Plantas Medicinais , Próstata/efeitos dos fármacos , Glândulas Seminais/efeitos dos fármacos , Fosfatase Ácida/metabolismo , Administração Oral , Fosfatase Alcalina/metabolismo , Animais , Glucose/metabolismo , L-Lactato Desidrogenase/metabolismo , Masculino , Pós/farmacologia , Próstata/citologia , Próstata/enzimologia , Próstata/metabolismo , Ratos , Glândulas Seminais/citologia , Glândulas Seminais/enzimologia , Glândulas Seminais/metabolismoRESUMO
The histological and biochemical changes in the caput and cauda epididymis of albino rat treated with 20, 40 and 60 mg dry powder of the leaves of A. indica per day for 24 days are reported. In the treated rats, the height of the epithelium and the diameter of the nucleus in both the regions were reduced. The lumen of the caput was packed with lymphocytes. Biochemically, a decrease in the protein content and acid phosphatase activity and an increase in the alkaline phosphatase and lactate dehydrogenase activities were observed in both the regions. The effect was dose dependent. Further, serum testosterone concentration in the higher dose treated animals decreased significantly. The results suggest a possible antiandrogenic property of the leaves of A. indica.
