RESUMO
A simple and efficient separation method of carrier-free 47Sc from neutron irradiated titanium target using a novel chitosan-acrylic acid/multiwalled carbon nanotubes (CS-AA/MWCNTs) composite was established. The synthesis of the CS-AA/MWCNTs composite was achieved using gamma radiation-induced template polymerization. The grafting efficiency (GE%) of AA on CS onto the surface of f-MWCNTs reached a maximum of~84% under the optimized conditions (30 wt% CS, 1.0 wt% AA, 0.15 wt% f-MWCNTs, >0.2 wt% N,N'-Methylenebisacrylamide (NMBA), and irradiation dose ~25 kGy). Different analyses (FT-IR, SEM, TGA and DTA) were examined for confirming the structural morphology and mechanical properties of the new synthesized composite. Interestingly, the CS-AA/MWCNTs composite depicted a selective adsorption of Sc(III) rather than Ti(IV) ions at pH 5 with adsorption efficiency of ~93.93%. The ionic exchange separation of no-carrier-added (NCA)47Sc(III) from irradiated TiO2 target on CS-AA/MWCNTs composite packed column efficiently eluted 47Sc(III) by 91 ± 0.8% using 1 M HCl solution. The quality control tests (radionuclidic, radiochemical, and chemical purities) for the eluted 47Sc(III) clarified its high purity and validity for cancer theranostics.
Assuntos
Acrilatos/química , Quitosana/química , Resinas Compostas/síntese química , Nanotubos de Carbono/química , Nêutrons , Radioisótopos/isolamento & purificação , Escândio/isolamento & purificação , Titânio/química , Adsorção , Cromatografia Líquida , Resinas Compostas/química , Análise Diferencial Térmica , Concentração de Íons de Hidrogênio , Microscopia Eletrônica de Varredura , Nanotubos de Carbono/ultraestrutura , Polimerização , Medicina de Precisão , Radioisótopos/análise , Radioisótopos/química , Escândio/análise , Escândio/química , Espectroscopia de Infravermelho com Transformada de Fourier , Propriedades de Superfície , Termogravimetria , Titânio/efeitos da radiaçãoRESUMO
Poly (acrylamide-acrylic Acid)/multi-walled carbon nanotubes composite [P(AAm-AA)/MWCNTs] was prepared by gamma radiation to initiate the copolymerization of AAm and AA onto MWCNTs surface. The structural characteristics were confirmed by FT-IR, SEM, XRD, TGA and DTA. The particle size distribution was determined by dynamic light scattering (DLS). [P(AAm-AA)/MWCNTs] was used to study the adsorption efficiency of 47Sc from natural calcium by batch technique at different concentrations of HCl and/or HNO3 acid solutions. No-carrier-added 47Sc (III) was separated from 47Ca(II) on [P(AAm-AA)/MWCNTs] column matrix. The elution efficiency of about 80⯱â¯1.5% was attained for 47Sc(III) using 1M HNO3. Three quality control tests, radionuclidic, radiochemical and chemical purities were investigated to emphasis that 47Sc secure for use in nuclear medicine.
