An Asian patient with intraocular lymphoma treated by intravitreal methotrexate.

BACKGROUND: To demonstrate the efficacy of intravitreal methotrexate for treating intraocular lymphoma. CASE: A 55-year-old immunocompetent Asian man was diagnosed with intraocular lymphoma. OBSERVATIONS: The patient was initially managed by intravenous administration of high-dose methotrexate. Because vitreous cells persisted after systemic chemotherapy, methotrexate was given intravitreally thereafter. There was only self-limited corneal epitheliopathy without major complications following intraocular injections. Ocular remission was sustained during a 21-month follow-up. CONCLUSION: Intravitreal methotrexate is an effective, repeatable, and safe treatment for intraocular lymphoma.