RESUMO
AIM: To investigate the expression and clinical significance of FOXO4 in colorectal cancer tissues. METHODS: Immunohistochemistry assay was performed to detect the FOXO4 expression in 80 colorectal cancer and matched noncancerous tissues (18 cases in stage I, 32 in stage II, 24 in stage III and 6 in stage IV). The relationship between FOXO4 expression and the patients' clinicopathologic features including gender, differentiation and TNM staging was also analyzed. RESULTS: The positive expression rate of FOXO4 protein in colorectal cancer tissues was 47.50%, which was significantly lower than that in matched noncancerous tissues (91.25%, P