MGGAN: A multi-generator generative adversarial network for breast cancer immunohistochemical image generation.

The immunohistochemical technique (IHC) is widely used for evaluating diagnostic markers, but it can be expensive to obtain IHC-stained section. Translating the cheap and easily available hematoxylin and eosin (HE) images into IHC images provides a solution to this challenge. In this paper, we propose a multi-generator generative adversarial network (MGGAN) that can generate high-quality IHC images based on the HE of breast cancer. Our MGGAN approach combines the low-frequency and high-frequency components of the HE image to improve the translation of breast cancer image details. We use the multi-generator to extract semantic information and a U-shaped architecture and patch-based discriminator to collect and optimize the low-frequency and high-frequency components of an image. We also include a cross-entropy loss as a regularization term in the loss function to ensure consistency between the synthesized image and the real image. Our experimental and visualization results demonstrate that our method outperforms other state-of-the-art image synthesis methods in terms of both quantitative and qualitative analysis. Our approach provides a cost-effective and efficient solution for obtaining high-quality IHC images.

[Effects of shuang shen tong guan decoction on the blood flow dynamics in rat model with myocardial infarction].

OBJECTIVE: To research the effects of Shuang Shen Tong Guan Decoction (SSTGD) on hemodynamics in rats with acute myocardial infarction (AMI). METHODS: SD rats were divided into sham operation group,model group, SSTGD low-dose group (2.5 g/kg), SSTGD middle-dose group (5 g/kg) and SSTGD high-dose group (7.5 g/kg). The levels of HR, MAP, LVSP, LVEDP, LVdp/ dt(max) and LVdp/dt(min) were detected by PowerLab at 0, 15, 30, 60, 90, 120, 180 min after administration. RESULTS: Compared with the sham operated group, the levels of HR, MAP were increased, the levels of LVSP, LVEDP, LVdp/dt(max) and LVdp/dt(min) were reduced at each detected point in model group, the difference was significant (P < 0.05). Compared with the model group, HR and MAP were decreased in SSTGD low-dose group, SSTGD middle-dose group and SSTGD high-dose group after 15 min; LVSP, LVEDP, LVdp/dt(max) and LVdp/dt(min) were higher, there was significantly difference (P < 0.05). Compared with SSTGD low-dose group and SSTGD middle-dose group, the difference of LVSP, LVEDP, LVdp/dt(max) and LVdp/dt(min) was statistically significant in SSTGD high-dose group (P < 0.05). CONCLUSION: SSTGD can improve cardiac function by increasing heart stroke volume, decreasing cardiac oxygen consumption and total peripheral vascular resistance.