Heteroleptic pincer palladium(II) complex coated orthopedic implants impede the AbaI/AbaR quorum sensing system and biofilm development by Acinetobacter baumannii.

Implant-associated infections mediated by Acinetobacter baumannii biofilms have become a major concern in the healthcare sector. As biofilm formation by this important pathogen is mediated by quorum sensing, quorum sensing inhibitors (QSI) have gained much attention. The present study confirms that novel thiazolinyl-picolinamide based palladium(II) complexes had good biofilm disruptive and QSI properties against A. baumannii. Key QS-mediated virulence factors like pili mediated surface motility and polysaccharide production were inhibited by the best Pd(II) complex (E). This also showed potent inhibitory activity against both the standard and clinical strains of A. baumannii. Molecular docking analysis also proved the potent binding affinity of Pd(II)-E with the virulence targets. The Pd(II) complex also disrupted preformed biofilms and down-regulated the expression of QS mediated virulence genes in the biofilms established on implant material (titanium plates). As a whole, the present study showed that the novel thiazolinyl-picolinamide based Pd(II) complexes offer a promising anti-infective strategy to combat biofilm-mediated implant infections.

An isolated middle cuneiform dislocation with a rare violence. Case report and literature review.

OBJECTIVE: To report how a case of isolated middle cuneiform dislocation is diagnosed mainly by suspicion and careful imaging. CLINICAL PRESENTATION AND INTERVENTION: A 39-year-old male presented with localized foot pain after a sideways compression of the foot on ground. X-rays revealed an empty middle cuneiform site .CT confirmed the finding of an isolated middle cuneiform dislocation .He had operative reduction and stabilization, followed by a good foot function. CONCLUSION: The diagnosis of such an injury should be kept in mind in patients while examining the foot injuries in general. Imaging including CT scan of the foot is necessary to confirm the diagnosis and to plan for the surgical treatment. The case was presented to highlight the need to watch out for them and care for them at the earliest.