RESUMO
BACKGROUND: Gastric carcinoma is frequently refractory to chemotherapy. The multidrug resistance 1 gene (MDR1) encodes for a protein (p-glycoprotein) that functions as a drug efflux pump and thus contributes to resistance to chemotherapeutic agents. METHODS: We studied gastric tissues from 28 patients with gastric cancer for MDR1 expression, using immunohistochemistry. RESULTS: Sixteen (57%) of 28 cases showed MDR1 expression. Sections of normal mucosa away from the tumor showed perinuclear staining for MDR1 in surface epithelial cells, whereas tumor cells showed diffuse cytoplasmic positivity. CONCLUSIONS: Over one half of gastric carcinoma specimens at our center show MDR1 gene expression.
Assuntos
Genes MDR/fisiologia , Neoplasias Gástricas/genética , Idoso , Feminino , Expressão Gênica , Humanos , Imuno-Histoquímica , Índia , Masculino , Pessoa de Meia-Idade , Estudos SoroepidemiológicosRESUMO
A case of primary pulmonary lymphoma, small lymphocytic type, with plasmacytoid differentiation (lymphoplasmacytic lymphoma) and IgM gammopathy, was diagnosed by fine needle aspiration of the lung. It was further substantiated by pleural fluid cytology, biochemical and immunologic parameters, and the clinical picture. This case is documented for its rarity along with a review of literature on the diagnosis of low grade small lymphocytic lymphomas.