1.
Indian J Ophthalmol
; 69(8): 2111-2115, 2021 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34304188
RESUMO
Purpose: This study is aimed to investigate the presence of Human papillomavirus (HPV) DNA in tumors obtained from sporadic retinoblastoma patients. Methods: One hundred six tumor tissues obtained from sporadic RB patients were analyzed for HPV infection by use of both seminested PCR and real-time quantitative PCR. Results: Of 106 RB patients, 55 were male and 51 were female. The mean age at diagnosis was 26.77 ± 15.36 (mean ± Std. dev) months. Almost all patients presented with leukocoria. Molecular investigation by different methods revealed no HPV positivity in any tumor genome. Conclusion: Our study demonstrates no association between HPV and RB, postulating HPV may not be a major risk factor in the etiology of RB.
Assuntos
Alphapapillomavirus , Infecções por Papillomavirus , Neoplasias da Retina , Retinoblastoma , Feminino , Humanos , Índia/epidemiologia , Masculino , Papillomaviridae/genética , Infecções por Papillomavirus/diagnóstico , Infecções por Papillomavirus/epidemiologia , Reação em Cadeia da Polimerase em Tempo Real , Neoplasias da Retina/diagnóstico , Neoplasias da Retina/epidemiologia , Retinoblastoma/diagnóstico , Retinoblastoma/epidemiologia
2.
Pediatr Blood Cancer
; 68(1): e28553, 2021 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32672397