1.
J Asian Nat Prod Res
; 13(9): 805-10, 2011 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21830884
RESUMO
From the roots of Euphorbia pekinensis, two new casbane diterpenoids, named pekinenins A (1) and B (2), were isolated. Their structures were elucidated as 18-hydroxy-1ßH,2αH-casba-3E,7E,11E-trien-5-one (1), 5α-methoxy-1ßH,2αH-casba-3Z,7E,11E-trien-18-oic acid (2) by a combination of 1D and 2D NMR spectroscopy and mass spectrometry. In the cytotoxicity assay of the two new compounds against Hela, MCF-7, and C6 human cancer cell lines, compound 1 showed moderate cytotoxic activity against two human cancer cell lines, Hela and C6, with IC(50) values of 42.97 and 50.00 µM, respectively.