1.
Zhonghua Zhong Liu Za Zhi
; 16(5): 360-3, 1994 Sep.
Artigo
em Chinês
| MEDLINE
| ID: mdl-7895588
RESUMO
Bone marrow specimens from 100 cases of acute leukemia (AL) diagnosed by MIC were detected with fluorescence microscopy for their mdr-1 expression using monoclonal antibody JSB-1 against P-glycoprotein (P-170). The results showed that almost all subtypes of AL had P-170 expression and M5 of ANLL had a significantly higher expression rate in the newly diagnosed group. The MDR expression highly correlated with the clinical drug resistance and prognosis. The Positive rate of P-170 (20.8% +/- 14.9%) and MDR expression (78.9%) of refractory group were significantly higher than newly diagnosed group (7.5% +/- 9.8% and 18.2% respectively). Cases with MDR expression had poor response to chemotherapy and bad prognosis.
Assuntos
Membro 1 da Subfamília B de Cassetes de Ligação de ATP/biossíntese , Resistência a Múltiplos Medicamentos/genética , Leucemia Monocítica Aguda/genética , Leucemia Mieloide Aguda/genética , Anticorpos Monoclonais , Expressão Gênica , Humanos , Leucemia Mielomonocítica Aguda/genética , Leucemia-Linfoma Linfoblástico de Células Precursoras/genética , Prognóstico
2.
Proc Chin Acad Med Sci Peking Union Med Coll
; 3(3): 133-8, 1988.
Artigo
em Inglês
| MEDLINE
| ID: mdl-3217415
