[The asthenic syndrome and mental work capacity]. / Astenicheskii sindrom i psikhicheskaia rabotosposobnost'.

Investigation of the development of the asthenic syndrome during neuropsychic overload and its impact on dynamics of psychic performance in operators is of great interest to many specialists engaged in clinical and applied medicine. The paper presents results of clinicopsychologic and clinico-neurophysiologic studies of 105 persons in intellectual and operational professions who were treated in Moscow Clinic of neurosis in connection with the asthenic syndrome caused by professional overload or emotional stress. The obtained data showed that development of the asthenic syndrome had certain stages depending on duration and severity of emotional, vegetative, dissomnic and other psychosomatic disorders. It was shown that, being one of the key integral indices of human adaptability, psychic performance retained on sufficiently high level for a long period during asthenic syndrome.

[Prevention of neuropsychiatric changes in hypokinesia]. / Profilaktika nervno-psikhicheskikh izmenenii pri gipokinezii.

The article deals with the comparative evaluation of the prophylactic efficacy of exercise, muscular electrostimulation, psychotherapy, and hypoxic gaseous mixtures in hypokinesia in the form of staying in bed for up to 182 days. Exercise of a magnitude of 600 kcal/day was found to be most effective, with electrostimulation, psychotherapy, and hypoxic gaseous mixture being less effective. The advisability of the combined use of prophylactic means has been proved.

[Changes in the nervous system during prolonged hypokinesia (clinico-experimental study)]. / Izmeneniia nervnoi sistemy pri dlitel'noi gipokinezii (kliniko-éksperimental'noe issledovanie).

A combined clinical and neurophysiological study of 12 clinically healthy subjects under conditions of strict bed regimen was carried out. The data obtained have shown that hypokinesia in initially healthy subjects induces a complex of neurological changes expressed as the neurosis-like vegetative-dystonic syndrome attended with reflectory-motor and cerebrovascular disorders. Similar alterations prevail in patients with "nosogenic" hypokinesia when the motor sphere is impaired. Muscular electrostimulation is proved advisable as a therapeutic-prophylactic means for hypokinetic changes in the nervous system.

[Change in the neuromotor apparatus after 45 days' hypokinesia]. / Izmenenie neiromotornogo apparata pri 45-sutochnoi gipokinezii.

Neurological and electromyographic examinations of 12 test subjects during a 45-day bed rest study were carried out. Symptoms indicating changes in the suprasegmentary innervation were noted. Shortening of the duration of potentials was shown by needle electromyography. A decline in the threshold of H-reflex and a change in the frequency parameters of EMG were seen. These data suggest a change in the functional state of the central and peripheral motor neuron during prolonged hypokinesia. Prophylactic efficiency of muscle electrostimulation is discussed.

[Primary localization of the pathologic process in amyotrophic lateral sclerosis]. / O pervichnoi lokalizatsii patologicheskogo protsessa pri bokovom amiotroficheskom skleroze.

The clinico-electromyographical study was conducted in 120 patients with motor disturbances in amyotrophical lateral sclerosis. Comparing the clinical and electromyographical data in different variants of this disease the authors make a conclusion on the simultaneous damage of peripheral and central mononeurons from the very onset of the disease. Along with this the latter is damaged not only primarily, but secondarily as a result of trans-synaptic degerneration due to pathology of the segmental-nucleus motor cells.