[Chronic fatigue syndrome:objective criteria of metabolic defects]. / Sindrom khronicheskogo utomleniia: ob"ektivnye kriterii metabolicheskikh narushenii.

Multi-level system of defense mechanisms is studied in 206 normal subjects living in an ecologically unfavorable region and working at chemical plants. Control group consisted of 24 subjects living in en ecologically safe region. The content of total protein and albumin and its effective and binding capacity were decreased, while the content of medium molecular weight peptides increased in the blood of subjects exposed to technogenic environmental pollution. The detected shifts are regarded as a mechanism of development of chronic fatigue syndrome.