Evaluation of groundwater quality in and around Peenya industrial area of Bangalore, South India using GIS techniques.

Groundwater resource forms a significant component of the urban water supply. Declining groundwater levels in Bangalore Urban District is generally due to continuous overexploitation during the last two decades or more. There is a tremendous increase in demand in the city for good quality groundwater resource. The present study monitors the groundwater quality using geographic information system (GIS) techniques for a part of Bangalore metropolis. Thematic maps for the study area are prepared by visual interpretation of SOI toposheets on 1:50,000 scale using MapInfo software. Physicochemical analysis data of the groundwater samples collected at predetermined locations form the attribute database for the study, based on which spatial distribution maps of major water quality parameters are prepared using MapInfo GIS software. Water quality index was then calculated by considering the following water quality parameters--pH, total dissolved solids, total hardness, calcium hardness, magnesium hardness, alkalinity, chloride, nitrate and sulphate to find the suitability of water for drinking purpose. The water quality index for these samples ranged from 49 to 502. The high value of water quality index reveals that most of the study area is highly contaminated due to excessive concentration of one or more water quality parameters and that the groundwater needs pretreatment before consumption.

Accuracy of uncorrected versus corrected QT interval for prediction of torsade de pointes associated with intravenous haloperidol.

STUDY OBJECTIVE: To determine if the uncorrected QT interval (QT(u)) more accurately predicts drug-induced torsade de pointes than QT intervals corrected using the Bazett's (QT(B)), Fridericia (QT(Frid)), or Framingham (QT(Fram)) methods. DESIGN: Retrospective analysis of a previously reported case-control study of risk factors for haloperidol-induced torsade de pointes. SETTING: Large tertiary care teaching hospital. PATIENTS: Forty-six critically ill patients who received intravenous haloperidol for sedation; seven developed torsade de pointes. MEASUREMENTS AND MAIN RESULTS: The QT intervals were measured manually by one investigator from electrocardiograms performed before and during haloperidol therapy. Logistic regression analysis for prediction of torsade de pointes was performed, incorporating QT(u), QT(B), QT(Frid), QT(Fram), and RR intervals measured during treatment. Receiver operating characteristics (ROC) curves were constructed. Primary outcome measures were proportion of explained variation (maximum-rescaled R2); area under the ROC curves for QT(u), QT(B), QT(Frid), QT(Fram), and RR interval; and sensitivity and specificity for prediction of haloperidol-induced torsade de pointes. The QT(u) was associated with the highest R2 compared with QT(Fram), QT(Frid), QT(B), and RR interval (0.77, 0.73, 0.68, 0.53, and 0.30, respectively). No significant differences in areas under the ROC curves were found between any of the QT-interval methods. Areas under the ROC curves for QT(u) and QT(Fram) trended toward being greater than that associated with the RR interval. All QT-interval methods were highly sensitive (100% for each), whereas the RR interval was less sensitive (86%); QT(u) and QT(Fram) were most specific (82%) compared with the QT(Frid) (72%), QT(B) (64%), and RR interval (36%). CONCLUSION: Compared with QT(B) and QT(Frid), the QT(u) and QT(Fram) best predicted haloperidol-induced torsade de pointes in critically ill patients; the QT(Fram) offered no advantage over the QT(u).

Clinical presentation, hospital length of stay, and readmission rate in patients with heart failure with preserved and decreased left ventricular systolic function.

BACKGROUND: Congestive heart failure is the leading cause of hospital admissions for adults in the United States. To our knowledge, there are limited data comparing the clinical presentation, hospital length of stay, and readmission in patients with preserved and decreased left ventricular (LV) systolic function. HYPOTHESIS: The goal of the study was to determine whether there are differences in clinical presentation, hospital length of stay, and readmission in patients with preserved (> or = 50%) and reduced (< 50%) systolic function. METHODS: We prospectively evaluated 187 patients admitted with congestive heart failure confirmed by the presence of pulmonary vascular congestion on chest x-ray, and with recent (< 6 months) documentation of LV systolic function by two-dimensional echocardiography. History and physical examination findings, patient demographics, comorbidities, discharge medications, and length of hospital stay data were documented. Readmission rate over a 6-month follow-up period was also documented. RESULTS: Of the 187 patients, 130 (70%) patients had an ejection fraction (EF) <50%, and 57 (30%) patients had an EF > or = 50%. Patients with EF < 50% were more likely to be men (54 vs. 37%, p = 0.03). African Americans (79 vs. 60%, p = 0.007), had a higher prevalence of previous stroke (17 vs. 5%, p = 0.03), and were more likely to carry no medical insurance at the time of admission (14 vs. 2%, p = 0.01) and to be discharged on digoxin (60 vs.30%, p<0.001). There were no significant differences in symptoms (exertional dyspnea, rest dyspnea, orthopnea, or paroxysmal nocturnal dyspnea), or in physical examination findings (S3, S4, elevated jugular venous pressure, rales, or peripheral edema). According to chest x-ray, patients with EF <50% had more frequent cardiomegaly (88 vs. 72% p = 0.008), but there were no differences in the presence of pleural effusion or pulmonary vascular congestion (p = NS). The mean length of stay was 5.9 and 5.2 days, respectively (p = 0.34). During the 6-month follow-up period, the readmission rates were 33% (43 patients) and 26% (15 patients), respectively (p = 0.36). CONCLUSION: The clinical presentation, hospital length of stay, and readmission rate for congestive heart failure are similar in patients with preserved and decreased LV systolic function.