Evaluation of optimized molecular structure-antimicrobial and antioxidant efficacy relationship of Schiff bases.

The synthesis, reactivity, structure, antimicrobial potential, and antioxidant property of some Schiff bases were extensively studied experimentally and theoretically using the B3LYP method of DFT (density functional theory). Schiff bases formed with the interaction of salicylaldehyde and amino alcohols in a 1:1 molar ratio in ethanol. The physicochemical and spectroscopic investigations decide the plausible structure of these newly synthesized Schiff bases. The computational study can assess the molecular orbitals, chemical reactivity, stability, and molecular electrostatic potential of Schiff bases. The thermodynamic parameters and optimized structures of Schiff bases in the gaseous state investigated by the B3LYP method of DFT. The evaluation of Schiff bases possesses antimicrobial resistance against gram-negative (Pseudomonas aeruginosa) and (Bacillus cereus)gram-positive bacterial strains as well as fungal strains (Candida albicans and Penicillium chrysogeum). The MIC (minimum inhibitory concentration) of all Schiff bases against Bacillus cereus was found in the range of 250 to 1200 µg. The MIC values of L1H, L2H, and L3H against Penicillium chrysogeum were 400, 600, and 800 µg, respectively, whereas the MIC value of L1H against Candida albicans was 600 µg. The free radical scavenging activity by the DPPH method was used to access potential antioxidant activity in Schiff bases.

Transpupillary thermotherapy for treatment of choroidal neovascularization secondary to age-related macular degeneration in Indian eyes.

AIM: To evaluate the efficacy of transpupillary thermotherapy (TTT) for treatment of subfoveal choroidal neovascularisation (CNV) secondary to age-related macular degeneration (AMD), and to define accurate power settings for this procedure in Indian eyes. METHODS: A prospective, nonrandomised study of 160 eyes of 144 patients with subfoveal CNV. The laser settings included 2 mm spot and 300 mw power or 3 mm spot and 400-600 mw power. Two separate 3 mm spots were used in larger lesions. The treatment was given for 60 seconds at each point. RESULTS: Ninety-nine eyes had classic membranes and 61 eyes had occult membranes. Following treatment, 79 of 99 (79.8%) classic and 52 of 61 (85%) occult membranes regressed. Visual improvement (> or = 2 lines) was seen in 29 (29.3%) eyes and 12 (19.6%) eyes; visual stabilisation (1 line) in 39 (39.4%) eyes, and 35 (57.4%) eyes; and reduction of vision (< or = 2 lines) in 31 (31.3%) eyes and 14 (22.9%) eyes with classic and occult membranes respectively. Mean follow-up was 12 months. One patient suffered inadvertant foveal burn. CONCLUSION: TTT is effective in the management of subfoveal membranes in Indian eyes. They respond to lower energy levels compared to the Caucasian eyes.