[The use of H-1 antihistamine preparations in neurodermatitis patients]. / Primenenie H-1 antigistaminnykh preparatov u bol'nykh neirodermitom.

Correlations between clinical variants of neurodermatitis course and patients' lymphocyte sensitivity to histamine are analyzed. The atopic form is associated with high lymphocyte sensitivity to histamine. Administration of H-1 antihistaminic agents to these patients is not always justified. Antihistaminic drugs should be prescribed to neurodermatitis patients with due consideration for the individual sensitivity of patient's lymphocytes to histamine.

[Influence of carnosine on the immunosuppressive effect of histamine]. / Vliianie karnozina na immunosupressivnyi éffekt gistamina.

It has been demonstrated in experiments that histamine is capable of suppressing the antigen-induced proliferation of mouse spleen cells. This histamine effect was suppressed by its H-2 antagonist metiamide but not H-1 antagonist mepiramine. Carnosine exerted an action similar to metiamide, also inhibiting the histamine-caused suppression of murine lymphocyte proliferation. This makes it possible to classify it with the group of H-2-histamine blockers. The H-2-antihistamine properties exhibited by carnosine necessitate its further study as a new antiallergic drug.

[Determination of the antihistaminic properties of histidine derivatives on models of guinea pig T- and B-lymphocyte rosette formation]. / Opredelenie antigistaminnykh svoistv u nekotorykh proizvodnykh gistidina na modeliakh T- i B-rozetkoobrazovaniia limfotsitami morskikh svinok.

It was found that carnosine, like metiamide, an H-2 antagonist of histamine, is capable of inhibiting the histamine caused suppression of T rosette-formation by guinea-pig blood and spleen lymphocytes. The other histidine derivatives, imidazole lactate, imidazole pyruvate and N-acetyl histidine did not exhibit such properties. The data obtained allow classifying carnosine with H-2-histamine blockers and serve as one of the explanations of the mechanism of its antiallergic action.