RESUMO
Hair loss was compared between surgery followed by craniospinal radiotherapy (CSRT) or chemotherapy then CSRT (C-CSRT) for medulloblastoma. The proportion of patients exhibiting hair loss in the cranial field was 70.0% (C-CSRT) versus 30.0% (CSRT) (95% CI: 14.7% to 58.9%; P = 0.002). The C-CSRT group also experienced more virtual/complete hair loss over the posterior fossa boost. Age was a significant contributor to hair loss in the cranial field. Persistent significant hair loss is an under-reported late effect of treatment that could influence quality of survival and should be considered in future trial design.
Assuntos
Alopecia/etiologia , Neoplasias Infratentoriais/terapia , Tumores Neuroectodérmicos Primitivos/terapia , Adolescente , Fatores Etários , Criança , Pré-Escolar , Terapia Combinada , Feminino , Seguimentos , Humanos , Neoplasias Infratentoriais/tratamento farmacológico , Neoplasias Infratentoriais/radioterapia , Neoplasias Infratentoriais/cirurgia , Modelos Logísticos , Masculino , Tumores Neuroectodérmicos Primitivos/tratamento farmacológico , Tumores Neuroectodérmicos Primitivos/radioterapia , Tumores Neuroectodérmicos Primitivos/cirurgia , Fatores de RiscoRESUMO
Full-mouth disinfection is a relatively new technique for the management of patients, especially those with moderate to severe chronic periodontitis. In this paper, the technique is reviewed and efficacy evaluated. The methodology and possible outcomes are illustrated with a case report.
Assuntos
Anti-Infecciosos Locais/uso terapêutico , Periodontite Crônica/prevenção & controle , Profilaxia Dentária/métodos , Clorexidina/uso terapêutico , Raspagem Dentária/métodos , Feminino , Humanos , Pessoa de Meia-Idade , Antissépticos Bucais/administração & dosagem , Índice PeriodontalRESUMO
UNLABELLED: A variety of techniques have been used in an attempt to regenerate periodontal tissues. Studies have confirmed that considerable but varying amounts of new connective tissue attachment may form on teeth treated with these techniques. At present, careful case selection and meticulous surgical technique can regenerate the periodontium, although studies from the literature demonstrate a large variation in success rates. In the future, we can expect further developments from the field of tissue engineering to produce more predictable techniques that could allow us to regenerate lost periodontal tissues even more effectively. CLINICAL RELEVANCE: This paper reviews the current techniques that can be used to regenerate periodontal tissues and suggests some possible developments in this field that may influence future clinical practice.
