A Marker of Cerebral Ischemia in Solid State Structures of Blood Serum.

Reversible cerebral ischemia of medium severity was reproduced in male Wistar rats by bilateral occlusion of the common carotid arteries. Solid-phase structures (anisomorphons) were obtained by marginal dehydration of the serum. Small focal isotropic defects in the serum anisomorphon texture were found in 100% cases during occlusion of the carotid arteries. Similar signs were detected in all patients with chronic cerebral ischemia, which proved specificity of this morphological marker of the disease.

[Features of Urine Biomineralization in Long-Livers].

BACKGROUND: The increasing number of long-livers in the developed countries indicates the demand for clarification of the body vital systems' functioningfeatures which allow the long-livers to prolong their active involvement in social life. OBJECTIVE: Aim of our study/research was to define a functional condition of urinary system in long-livers using the new diagnostic technology which analyses the structures of biological liquid at its phase transition in a solid state. METHODS: A case series study was held. All long-livers suffered from atherosclerosis and its complications as well as from associated diseases. An exclusion criterion was acute conditions. The creatinine level in blood serum, indicators of common urine analysis and features of urine facies (using cuneiform dehydration) were defined. RESULTS: Participants included 60 long-livers (mean age 87.34±4.17 years) who were passing clinical laboratory tests at in-patient department of gerontological hospital. In urine facies of 41 (68.3%) long-livers a phenomenon of salt crystals distribution was identified. It presents the concentration of anisotropic salt crystals in the form of a ring in a regional facies zone. The tenfold increase in concentration of calcium and double increase in concentration of phosphorus in comparison with the central zone was detected in long-livers with a higher percent sulphur in the regional zone of urinefacies. CONCLUSION: The urine facies of the majority of long-livers have signs of age structure formation associated with a specific distribution of anisotropic salt crystals which fix detritus in its inert form to block the autointoxication.

[The physiological significance of proliferative and alterative processes].

This article is a brief review of publications dedicated to a problem of basic regularities of proliferative and alternative processes in health and disease and their physiological, general biological and special meaning. Historical background shows the evolution of scientists' viewpoints regarding essentials and reasons of diseases. The publication spotlights systematization of proliferative and alternative reactions in different pathophysiological processes. It is underlined that the development of morbid conditions can start not only with structural-functional changes, but also with failure of physiological processes of regulation. A principle of universality and balance of cell and humeral responses is taken as a basis of humoral-cell proliferation, which is provided, on one side by their conservatism and on the other side by their flexibility. Modern investigations confirm that various physiological reactions of proliferation in organism are allelically determined more frequently, and their disturbances may have epigenetic character. The main physiological meaning of proliferative and destructive processes remains their protective-adaptive role in organism, and their study and diagnostics keep an important section in recognition of various pathophysiological states.

[Current views of etiopathogenetic mechanisms underlying the development of chronic pyelonephritis in subjects of different age].

A literature review of the issues pertinent to etiology and pathogenesis of chronic pyelonephritis is presented. Different aspects of pathogenesis of the disease in selected age groups of the patients (from childhood to senility) are considered and analysed with special reference to the etiology of acute and chronic pyelonephritis as well as the risk factors of this disease.

[Peculiarities of diagnostics of weakly symptomatic clinical course of chronic pyelonephritis].

The difficulty of early diagnostics of weakly symptomatic clinical course of chronic pyelonephritis (CP) is attributable to the lack of adequate methods. We used a novel Litos system diagnostic technology based on morphological analysis of dehydrated biological fluid The aim of the study was to develop methods for CP diagnostics from morphological characteristics of urine at different stages of the disease. It included 108 patients aged 58+/-1.3 yr with CP and 24 practically healthy subjects. Standard examination of all patients was supplemented by the analysis of urine using the Litos system. It was shown that morphological picture of urine makes it possible to objectively detect not only complete remission or exacerbation of the disease but also partial remission and high risk of CH even in patients with weakly symptomatic clinical course of this pathology. In case of incomplete remission, the treatment requires adequate long-term (three-course) antibacterial therapy despite normal results of urine analysis and microbiological studies. Patients at high risk of CP need to be prescribed preventive phytotherapy.