[Radiation pathomorphosis in intensive preoperative hypoxic radiotherapy of stomach cancer]. / Luchevoi patomorfoz pri intensivnoi predoperatsionnoi gipoksiradioterapii raka zheludka.

The authors presented the results of pathomorphological investigations of surgical specimens of 110 stomach cancer patients following preoperative radiotherapy or hypoxyradiotherapy and radical operation. Single and total focal doses depended on oxygen percentage in the inhaled mixture and were 4-5 and 20-25 Gy, respectively. Radiation pathomorphosis was established in 62.8% of the patients (in 19.1% it was marked, in 13.5% it was absent, unclassified changes were noted in 23.6%). Short-term hypoxia resulted in no tumor "protection". Radiation changes in the stomach mucose in hypoxyradiotherapy were noted 2-3-fold less frequently than in radiotherapy, suggesting predominant "protection" of healthy tissues by hypoxia.

[Performance of hypoxic radiotherapy in malignant tumors taking atmospheric pressure into account]. / Provedenie gipoksiradioterapii zlokachestvennykh opukholei s uchetom atmosfernogo davleniia.

Hypoxic mixtures, delivered during hypoxic radiotherapy, must contain different values of the volume portion of oxygen depending on atmospheric pressure variations. The authors give a formula of calculation of a necessary volume portion of oxygen and tables of atmospheric pressure variations in Moscow as well as rated values of the volume portion of oxygen, applied to possible atmospheric pressure variations.

[Immediate results of hypoxiradiotherapy of malignant tumors]. / Neposredstvennye rezul'taty gipoksiradioterapii zlokachestvennykh opukholei.

The paper represents a comparative analysis of hypoxiradiotherapy of 202 patients with malignant tumors of different sites. A significant decrease (a 3.5-fold) in the number of severe local radiation reactions was noted in hypoxiradiotherapy of cancer of the esophagus, pancreas and metastases of seminoma to the retroperitoneal lymph nodes. A decrease in the number and intensity of general radiation reactions and the absence of pyo-inflammatory complications after radical operations were noted in preoperative large fractionated hypoxiradiotherapy of colon and lung cancer. The general number of radiation reactions was 12% less in hypoxiradiotherapy. Tumor regression after hypoxiradiotherapy did not slow down. Complete or considerable tumor resorption after irradiation against a background of gaseous hypoxia was noted in 74 +/- 7% of the patients and in 65 +/- 7% after radiotherapy alone. Hypoxiradiotherapy alone or before operation should be widely introduced into clinical practice of cancer dispensaries or radiological departments.