[Immunologic response of the body in thyroid gland involvement due to incorporation of varying doses of 131I]. / Immunologicheskie reaktsii organizma pri porazhenii shchitovidnoi zhelezy, vyzvannom inkorporirovaniem razlichnykh doz 131I.

The body's immunological responses were examined in thyroid damage caused by the incorporation of varying 131I doses. The in-take of 131I in doses of 37, 74, and 148 KBc/g body weight caused reductions in the murine blood concentrations of thyroxin following 30, 60, and 180 days. The blood levels of triiodothyronine decreased 180 days after administration of 131I in a dose of 74 KBc/g body weight and 30, 60, and 180 days after incorporation of the radioisotope in a dose of 148 KBk/g body weight. Decreased concentrations of the both hormones were followed by the suppression of a humoral immune response to sheep red blood cells, diminished cell-mediated immunity in the mixed culture of lymphocytes. The inhibition of immune responses was correlated with the changes in the level of triiodothyronine.