RESUMO
Simultaneous pancreas-kidney transplantation (SPKT) can improve long-term patient survival and restore endogenous insulin secretion in recipients with type 1 diabetes (T1D). There are currently few data on glucose fluctuations assessed by continuous glucose monitoring (CGM) after SPKT. Aim: to evaluate CGM-derived time in range (TIR) and glucose variability (GV) in patients with T1D and functioning pancreatic grafts after SPKT. Fifty-four CGM recordings from 43 patients, 15 men and 28 women, aged 34 (31; 39) years were analyzed. Time since SKPT was up to 1 year (group 1, n = 13), from 1 to 5 years (group 2, n = 15), and from 5 to 12 years (group 3, n = 26). TIR (3.9-10 mmol/L), Time Above Range (TAR), Time Below Range (TBR), and GV parameters were estimated. There were no differences in mean glucose (5.5 [5.1; 6.2], 5.9 [5.4; 6.2], and 5.9 [5.6; 6.7] mmol/L), TIR (97.6 [92.8-99.1], 97.2 [93.2; 99.1], and 97.5 [93.4; 99]%); TAR (0, 1.8 [1.3; 3.7], and 2.5 [2; 5]%), TBR (5 [3.3; 12.7], 4.1 [2.2; 10.1], and 3.5 [1.3; 6.5]%) and GV parameters between three groups (all p > 0.05). Thus, recipients with functioning pancreatic grafts demonstrate remarkably high TIR and low GV after SPKT.
RESUMO
OBJECTIVE: The creation of artificial gravity on board a space station is one of the promising methods for preventing health problems during space missions; a short-radius centrifuge (SRC) is the model of such a method on Earth. Our goal was to evaluate the sensitivity of bioimpedance polysegmental measurements for monitoring of the body regions' blood-filling redistribution and to analyze the dynamics of blood-filling redistribution during rotation in three SRC rotation modes. APPROACH: Nine healthy male volunteers have been observed under three SRC rotation modes with a maximum acceleration of 2.05 standard Earth gravity (g), 2.47 g, 2.98 g along the body vertical axis towards the legs with a rotation radius of 235 cm. The 5 kHz electrical resistance was evaluated using a bioimpedance analyzer in a polysegmental mode. MAIN RESULTS: Twenty-five correct records were made, of which four records were incomplete since the tests had to be stopped because the subjects were not feeling well. There was a blood-filling decrease in the head region; resistance increased to +15.4% ± 4.1% in the first SRC rotation mode. The electrical resistance of the leg regions decreased to -16.5% ± 2.3%. Slowdown of the SRC led to the reverse changes in resistance. The blood redistribution in the head and leg regions was independent of the mode of SRC rotation during the first 30 min, and varied on average by +10% and -15% respectively. SIGNIFICANCE: Bioimpedance monitoring is promising for detection and prediction of blood circulation changes during rotation on the SRC.
