RESUMO
Hypercholesterolemia was experimentally induced in rats which received diets with a high fat content (66% calories) and cholesterol loading (2.5% of ration). The therapeutic effect of lipids isolated from quick-frozen Far East sardines was tested on rats given 500 mg lipids daily. The content of the blood serum lipid fractions in the test animals decreased under the action of the sardines' lipids: the total cholesterol level dropped by 23%, beta-lipoprotein cholesterol by 29%, triglycerides by 15%; the content of beta-lipoproteins became normal. The blood coagulation time was diminished in rats receiving diets with a high content of fat and cholesterol, as compared to that in control animals; and it increased under the action of sardines' lipids. A conclusion has been made on the hypolipidemic property of Far East sardines' lipids that produce a therapeutic effect on the blood lipid metabolism in animals.
Assuntos
Peixes , Hipercolesterolemia/tratamento farmacológico , Lipídeos/uso terapêutico , Animais , Avaliação Pré-Clínica de Medicamentos , Hipercolesterolemia/sangue , Lipídeos/sangue , Masculino , Ratos , Fatores de TempoRESUMO
The hypocholesteremic effect displated by the Japan Sea trepang is shown. The experiments were carried out on rabbits with hypocholesteremia caused by fasting. Total cholesterol, beta-lipoproteids, lipoid phosphorus, total phospholipids and the cholesterol/phospholipids ratio were determined in the blood of hypercholesteremic animals. The introduction of total trepang lipids to the hypercholesteremic fasting rabbits resulted in normalization of the lipids metabolism, this being indicative of the favourable effect produced by such lipids.