[Pathogenetic mechanisms of development of myocardial pathology in patients with malignant tumors: the current state of the problem].

The myocardium, which has a high metabolic activity, responds to metabolic disorders and energy imbalance induced by a growing malignant tumor. In addition, the tumor itself can produce substances that directly affect metabolic processes and the life cycle of cells not involved in the neoplastic process, including cardiomyocytes. This review summarized and systematized current data on individual aspects of detrimental effects of oncogenes and tumor-related factors on the heart muscle and morpho-functional changes in the cardiovascular system of oncology patients. Also, the authors described in detail development of these pathogenetic mechanisms.

[Sensitivity of clinical strains of Neisseria gonorrhoeae circulating in Yekaterinburg and the Sverdlovsk region].

The paper presents the results of determination of sensitivity of 154 gonococcal strains isolated from the patients, who were treated at the clinic of the Urals Research Institute of Dermatovenereology and Immunopathology and the Sverdlovsk Regional and Yekaterinburg City Dermatovenereological Dispensaries in 2001-2003, to penicillin, tetracycline, ciprofloxacin, ceftriaxone, spectinomycin, sparfloxacin, and moxifloxacin. It also shows the preponderance of moderately penicillin-resistant gonococci (75.3%) and their trend towards their transformation to resistant strains, tetracycline-resistant (74.0%), ciprofloxacin-sensitive (89%), and ceftriaxone-sensitive (82.5%) strains, as well as the absence of Neisseria gonorrhoeae resistant to spectinomycin, sparfloxacin, and moxifloxacin.

[Gastrin, gamma-endorphin and somatostatin cells of the stomach and duodenum in patients with duodenal ulcer treated with dalargin]. / Gastrinovye, gamma-éndorfinovye i somatostatinovye kletki zheludka i dvenadtsatiperstnoi kishki u bol'nykh iazvennoi bolezn'iu dvenadtsatiperstnoi kishki pri lechenii dalarginom.

The distribution of gastrin-, gamma-endorphin and somatostatin-producing cells in antral and duodenal mucosa was studied in biopsies from 26 patients with duodenal ulcer and from 13 controls by the immunohistochemical (PAP) method. The number of antral somatostatin-producing cells after dalargin treatment was significantly higher in comparison with controls and patients treated with antacids plus atropine. These changes may be connected with the antiulcer activity of dalargin, a new opioid peptide drug.