RESUMO
Results of the study evidence that in the early period of acute experimental pancreatitis (AEP)--from 10 minutes to 2 hours--changes in acino-capillary complex consist in compensatory-adaptive reaction and are related to metabolic disorders. Abortive interstitial oedema disappears in 20-30-minutes, dilated lymphatic vessels being visible macroscopically. Further progress of oedema with consequent focal haemorrhagic pancreonecrosis is possible in case of insufficient lymphatic drainage. The latter may be due both to destruction of lymphatic endotheliocytes and barrage of lymphatic ways with agglutinates. This indicates primacy of enzymatic alteration of pancreatocytes and secondary nature of vascular changes as well as necessity of early intensive care aimed at correction of lympho- and haemocirculation.
Assuntos
Linfa/fisiologia , Pâncreas/irrigação sanguínea , Pancreatite/fisiopatologia , Doença Aguda , Animais , Modelos Animais de Doenças , Cães , Histocitoquímica , Microcirculação/metabolismo , Microcirculação/fisiopatologia , Microcirculação/ultraestrutura , Pâncreas/metabolismo , Pâncreas/ultraestrutura , Pancreatite/metabolismo , Fatores de TempoRESUMO
At 12 preparations of the upper extremities of still-born fetuses has been studied microcirculatory channel of long bones of a hand. Clinical confirmation of the experimental results is based on the analysis of data obtained in process of treatment of 54 children with instable fractures of phalanges and metacarpal bones. An arterial channel of long bones of a hand is formed by the branches of finger arteries and vessels of the surrounding tissues. Epiphysis, metaphysis and growth cartilage have common circulatory system. The types of phalanx epiphysiolysis determine the terms of the open reposition realization. Comparison of morphological data and clinical observations demonstrated that the optimal methods of fixation of instable fractures of long bones of a hand are as follows: diafixation by means of wires, intramedullary osteosynthesis and perosseous compressive-distractive osteosynthesis.
Assuntos
Ossos do Carpo/lesões , Traumatismos dos Dedos/cirurgia , Dedos/cirurgia , Fixação Intramedular de Fraturas/métodos , Fraturas Ósseas/cirurgia , Metacarpo/cirurgia , Artérias/lesões , Artérias/patologia , Pinos Ortopédicos , Ossos do Carpo/irrigação sanguínea , Criança , Dedos/irrigação sanguínea , Fixação Intramedular de Fraturas/instrumentação , Hemorragia/prevenção & controle , Humanos , Metacarpo/irrigação sanguíneaRESUMO
In the experiment on 15 mongrel dogs, the pancreatoduodenal resection (PDR) with cholecystopancreatoanastomosis (CPA) formation was modelled. The advantages of CPA over pancreatojejunostomy were confirmed by morphological and histochemical investigations. In the institute of Clinical and Experimental Surgery, from 1983 to 1987, 73 PDRs were performed with CPA creation. Complications were noted in 34.2%, 9.6% of the patients died. The long-term results studied in 74.2% of the patients, in average, 26.6 mos after the intervention are good.