1.
J Org Chem
; 87(23): 16099-16105, 2022 Dec 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36377651
RESUMO
A copper(II)-promoted denitrogenation/oxidation reaction for the preparation of primary α-ketoamides was developed using α-azido ketones as a substrate and TEMPO as an oxidant. α-Azido ketones were denitrogenated in situ to form an imino ketone intermediate, which underwent a radical addition process and radical migration to form α-ketoamides. It is worth noting that the imino ketone intermediate is the key to this reaction.