RESUMO
BACKGROUND: Current guidelines recommend anticoagulation prior to cardioversion in patients with atrial fibrillation of >48 h or unknown duration to reduce thromboembolic risk. Therapeutic anticoagulation with warfarin, with INR between 2 and 3, is consistently achieved in approximately 60% of patients. AIMS: We evaluated outcomes and assessed differences in direct current cardioversion (DCCV) in patients treated with warfarin and novel oral anticoagulants (NOAC) at our institution. METHODS: A retrospective analysis of consecutive DCCV at a tertiary referral over 18 months was conducted. Analysis of cardioversion records allowed completion of a standardised dataset. Clinical variables recorded included (1) CHADSVASC score, (2) anticoagulant use, and (3) bleeding complications. RESULTS: During this period 187 DCCVs were scheduled; 119 on warfarin and 68 on NOAC. DCCV was deferred in 26% (n = 31) of the warfarin group and 4.4% (n = 3) of the NOAC group (p = 0.0002). The average time interval between referral and DCCV was 144.43 and 109.32 days for the warfarin and NOAC groups, respectively (p value = 0.023). 7.56% (n = 9) of the warfarin population had a bleeding event compared to a 2.94% total bleeding rate in NOAC group (p = 0.213). Deferral of elective DCCV and additional anticoagulant monitoring was estimated at 1160 per procedure. CONCLUSION: In elective cardioversions, the group anticoagulated with NOAC was less likely to have subtherapeutic anticoagulation and hence deferred procedures and had reduced health care consumption when compared to the group anticoagulated with warfarin.
Assuntos
Anticoagulantes/uso terapêutico , Fibrilação Atrial/terapia , Cardioversão Elétrica/métodos , Varfarina/uso terapêutico , Idoso , Anticoagulantes/administração & dosagem , Anticoagulantes/farmacologia , Fibrilação Atrial/patologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Avaliação de Resultados em Cuidados de Saúde , Estudos Retrospectivos , Centros de Atenção Terciária , Varfarina/administração & dosagem , Varfarina/farmacologiaAssuntos
Arritmias Cardíacas/diagnóstico , Arritmias Cardíacas/fisiopatologia , Eletrocardiografia , Técnicas Eletrofisiológicas Cardíacas , Síncope/diagnóstico , Síncope/fisiopatologia , Arritmias Cardíacas/complicações , Arritmias Cardíacas/etiologia , Arritmias Cardíacas/cirurgia , Fibrilação Atrial/diagnóstico , Fibrilação Atrial/fisiopatologia , Flutter Atrial/diagnóstico , Flutter Atrial/fisiopatologia , Ablação por Cateter , Morte Súbita Cardíaca/etiologia , Humanos , Valor Preditivo dos Testes , Síncope/cirurgia , Taquicardia por Reentrada no Nó Atrioventricular/diagnóstico , Taquicardia por Reentrada no Nó Atrioventricular/fisiopatologia , Taquicardia Supraventricular/diagnóstico , Taquicardia Supraventricular/fisiopatologiaAssuntos
Cardiomiopatia Dilatada/terapia , Marca-Passo Artificial , Idoso , Estimulação Cardíaca Artificial , Cardiomiopatia Dilatada/fisiopatologia , Ecocardiografia Tridimensional , Feminino , Insuficiência Cardíaca/fisiopatologia , Insuficiência Cardíaca/terapia , Hemodinâmica/fisiologia , HumanosRESUMO
There are two forms of nuclear loss from eukaryotic cells: biochemical DNA degradation in apoptosis and nuclear extrusion from the cell body as seen in mammalian erythroblasts. In biopsies of right ventricular myocardium from 8 patients with arrhythmogenic right ventricular dysplasia (ARVD), we found not only a terminal deoxynucleotidyl transferase-mediated digoxigenin-deoxyuridine triphosphate nick-end labeling (TUNEL)-positive nucleus in mononuclear myocytes, but also 1 or 2 TUNEL-positive nuclei in multinuclear myocytes. With electron microscopy, we found a nuclear dislocation to the cell periphery, followed by its extrusion into the extracellular space. Both the migration and extrusion of the nuclei of myocytes resemble the morphogenesis of human erythroblasts. Nuclear extrusion from myocytes may be another form of programmed cell death. In support of this possibility, we also found evidence of cytoplasmic degradation in right ventricular myocytes from our ARVD cases, a process similar to one often seen in developmental programmed cell death and differing from typical nuclear apoptosis. In our ARVD cases, we thus found several different patterns of cell death, all associated with initial preservation of the plasmalemma and avoidance of local inflammation. All these features may be different responses to common signals for selective non-necrotic (apoptotic) death of right ventricular myocytes.
Assuntos
Apoptose , Displasia Arritmogênica Ventricular Direita/patologia , Miocárdio/patologia , Adulto , Núcleo Celular/patologia , Núcleo Celular/ultraestrutura , Citoplasma/patologia , Citoplasma/ultraestrutura , Feminino , Histocitoquímica , Humanos , Marcação In Situ das Extremidades Cortadas , Masculino , Microscopia Eletrônica , Pessoa de Meia-Idade , Miocárdio/ultraestrutura , FagocitoseAssuntos
Doença das Coronárias/terapia , Stents , Idoso , Angioplastia Coronária com Balão/instrumentação , Angioplastia Coronária com Balão/métodos , Ponte de Artéria Coronária/efeitos adversos , Doença das Coronárias/diagnóstico por imagem , Humanos , Masculino , Infarto do Miocárdio/terapia , Revascularização Miocárdica/efeitos adversos , Radiografia , Recidiva , Veia Safena/transplante , Stents/efeitos adversos , Stents/estatística & dados numéricos , Stents/tendênciasRESUMO
Sudden cardiac death (SCD) may occur in as many as 40% of all patients who suffer from heart failure. This review describes the scope of the problem, risk factors for SCD, the effect of medications used in heart failure on SCD and the potential effect of the implantable cardioverter-defibrillator in primary prevention.
Assuntos
Morte Súbita Cardíaca/prevenção & controle , Desfibriladores Implantáveis , Insuficiência Cardíaca/terapia , Antagonistas Adrenérgicos beta/uso terapêutico , Inibidores da Enzima Conversora de Angiotensina/uso terapêutico , Antiarrítmicos/uso terapêutico , Bloqueadores dos Canais de Cálcio/uso terapêutico , Morte Súbita Cardíaca/epidemiologia , Morte Súbita Cardíaca/etiologia , Digoxina/uso terapêutico , Diuréticos/uso terapêutico , Insuficiência Cardíaca/mortalidade , Humanos , Fatores de RiscoRESUMO
HCM is a heterogeneous disease with various clinical presentations. Recent advances in understanding the genetic abnormalities responsible for ventricular hypertrophy promise to improve our ability to diagnose this condition and to identify subgroups who are at the highest risk of cardiovascular mortality. Numerous difficulties remain in treating patients with HCM, including obtaining relief of symptoms and preventing SCD, but several new treatment options are currently being evaluated. In the future, randomized trials comparing the major treatment options (eg, pharmacologic therapy, myotomy/myectomy, mitral valve replacement, pacemaker implantation, and nonsurgical septal reduction) will be needed to provide guidance concerning the optimal treatment of patients with HCM.
Assuntos
Cardiomiopatia Hipertrófica/diagnóstico , Adulto , Pressão Sanguínea/fisiologia , Cardiomiopatia Hipertrófica/epidemiologia , Cardiomiopatia Hipertrófica/fisiopatologia , Cardiomiopatia Hipertrófica/terapia , Ecocardiografia , Eletrocardiografia , Hemodinâmica , Humanos , Masculino , Pressão VentricularRESUMO
CONTEXT: Elevated plasma homocysteine is a known risk factor for atherosclerotic vascular disease, but the strength of the relationship and the interaction of plasma homocysteine with other risk factors are unclear. OBJECTIVE: To establish the magnitude of the vascular disease risk associated with an increased plasma homocysteine level and to examine interaction effects between elevated plasma homocysteine level and conventional risk factors. DESIGN: Case-control study. SETTING: Nineteen centers in 9 European countries. PATIENTS: A total of 750 cases of atherosclerotic vascular disease (cardiac, cerebral, and peripheral) and 800 controls of both sexes younger than 60 years. MEASUREMENTS: Plasma total homocysteine was measured while subjects were fasting and after a standardized methionine-loading test, which involves the administration of 100 mg of methionine per kilogram and stresses the metabolic pathway responsible for the irreversible degradation of homocysteine. Plasma cobalamin, pyridoxal 5'-phosphate, red blood cell folate, serum cholesterol, smoking, and blood pressure were also measured. RESULTS: The relative risk for vascular disease in the top fifth compared with the bottom four fifths of the control fasting total homocysteine distribution was 2.2 (95% confidence interval, 1.6-2.9). Methionine loading identified an additional 27% of at-risk cases. A dose-response effect was noted between total homocysteine level and risk. The risk was similar to and independent of that of other risk factors, but interaction effects were noted between homocysteine and these risk factors; for both sexes combined, an increased fasting homocysteine level showed a more than multiplicative effect on risk in smokers and in hypertensive subjects. Red blood cell folate, cobalamin, and pyridoxal phosphate, all of which modulate homocysteine metabolism, were inversely related to total homocysteine levels. Compared with nonusers of vitamin supplements, the small number of subjects taking such vitamins appeared to have a substantially lower risk of vascular disease, a proportion of which was attributable to lower plasma homocysteine levels. CONCLUSIONS: An increased plasma total homocysteine level confers an independent risk of vascular disease similar to that of smoking or hyperlipidemia. It powerfully increases the risk associated with smoking and hypertension. It is time to undertake randomized controlled trials of the effect of vitamins that reduce plasma homocysteine levels on vascular disease risk.
Assuntos
Arteriosclerose/sangue , Arteriosclerose/epidemiologia , Homocisteína/sangue , Adulto , Análise Química do Sangue , Estudos de Casos e Controles , Jejum , Feminino , Humanos , Hipercolesterolemia/sangue , Hipertensão/sangue , Modelos Logísticos , Masculino , Metionina/metabolismo , Pessoa de Meia-Idade , Fatores de Risco , Fumar/sangue , Doenças Vasculares/sangue , Doenças Vasculares/epidemiologiaRESUMO
This case report concerns an adverse device-device interaction between a replacement ICD and a dual chamber rate responsive pacemaker. It was observed that subtle changes in the design of sensing circuits between an older first-generation ICD and the newer third-generation ICD device led to unexpected and dramatic changes in the interactive behavior of a dual device system. The new ICD was connected to chronically implanted hardware. The sensing behavior of the newer ICD included a shorter time constant in the decay of the automatic gain control function, resulting in triple sensing of both the atrial and ventricular paced stimuli and the evoked QRS complex. Physicians should be aware of new design changes in the future so as to anticipate such interactions. In the setting of rapidly changing technology, extra caution must be exercised when choosing to implant two devices in the same patient.
Assuntos
Desfibriladores Implantáveis , Eletrodos Implantados , Marca-Passo Artificial , Idoso , Arritmias Cardíacas/terapia , Eletrocardiografia , Desenho de Equipamento , Humanos , Masculino , Telemetria , Fatores de TempoRESUMO
BACKGROUND: Some patients with otherwise typical AV node reentry do not manifest discontinuous AV node function curves. We examined the effects of an ablation in the slow-pathway region in patients with smooth AV node function curves. METHODS AND RESULTS: Fifteen patients with AV node reentrant tachycardia (AVNRT) and discontinuous AV node function curves were compared with 15 patients with AVNRT and smooth AV node function curves. In the group with discontinuous curve, the "net" anterograde effective refractory period (AERP) of the AV node increased (270 +/- 28 versus 304 +/- 37 ms, P = .03) and AERP of the remaining fast pathway decreased (367 +/- 100 versus 304 +/- 37 ms, P = .026) after the ablation. In the group with a smooth curve, the AERP of the AV node increased (266 +/- 42 versus 299 +/- 76 ms, P = .07) and the anterograde Wenckebach cycle length increased (336 +/- 66 versus 379 +/- 86 ms, P = .008) after the ablation. Retrograde conduction over the AV node was similar in both groups and was unchanged after ablation. The longest attainable AH interval (AHmax) measured during atrial extrastimulus testing was more prolonged in patients with a discontinuous curve than in patients with a smooth curve (326 +/- 48 versus 250 +/- 70 ms, P = .002). The AHmax shortened in both groups after ablation (326 +/- 48 versus 173 +/- 34 ms, P < .0001, and 250 +/- 70 versus 179 +/ 34 ms, P < .0003, respectively) and were similar. Successful ablation in the slow-pathway zone in patients with a smooth AV node function curve resulted in the loss of the "tail" of the curve representing the slow pathway. CONCLUSIONS: These data suggest that the smooth AV node function curve consists of two distinct components representing both fast and slow AV node pathways even when the typical discontinuity is absent.
Assuntos
Nó Atrioventricular/fisiopatologia , Taquicardia por Reentrada no Nó Atrioventricular/fisiopatologia , Ablação por Cateter , Eletrofisiologia , Sistema de Condução Cardíaco/cirurgia , Humanos , Taquicardia por Reentrada no Nó Atrioventricular/cirurgiaAssuntos
Estimulação Cardíaca Artificial , Ablação por Cateter , Bloqueio Cardíaco/terapia , Taquicardia Paroxística/cirurgia , Taquicardia Supraventricular/cirurgia , Idoso , Ablação por Cateter/efeitos adversos , Eletrocardiografia Ambulatorial , Feminino , Bloqueio Cardíaco/etiologia , Humanos , Taquicardia por Reentrada no Nó Atrioventricular/cirurgiaRESUMO
Percutaneous transluminal coronary angioplasty (PTCA) is a widely successful revascularisation procedure. The restenosis rate has not significantly improved, despite the addition of many therapeutic agents. We describe the role of intra-coronary stents in the management of recurrent occlusion, restenosis and intracoronary dissection. We describe and discuss the problems associated with placement of the stent. The intracoronary stent has a successful adjuvant role to play with angioplasty in reducing both the elective and emergency requirements for coronary artery bypass grafting.