Assuntos
Anormalidades Múltiplas/tratamento farmacológico , Fosfatase Alcalina/deficiência , Doenças do Desenvolvimento Ósseo/diagnóstico por imagem , Predisposição Genética para Doença , Hipofosfatasia/diagnóstico , Anormalidades Múltiplas/diagnóstico por imagem , Anormalidades Múltiplas/genética , Fosfatase Alcalina/genética , Doenças do Desenvolvimento Ósseo/tratamento farmacológico , Cesárea/métodos , Terapia de Reposição de Enzimas/métodos , Seguimentos , Humanos , Hipofosfatasia/complicações , Recém-Nascido , Masculino , Diagnóstico Pré-Natal/métodos , Doenças Raras , Síndrome do Desconforto Respiratório do Recém-Nascido/fisiopatologia , Síndrome do Desconforto Respiratório do Recém-Nascido/terapia , Resultado do TratamentoAssuntos
Dor Abdominal/etiologia , Ductos Biliares/diagnóstico por imagem , Ductos Biliares/lesões , Colecistectomia Laparoscópica/efeitos adversos , Cálculos Biliares/diagnóstico por imagem , Dor Pós-Operatória/etiologia , Dor Abdominal/diagnóstico por imagem , Dor Abdominal/cirurgia , Ductos Biliares/cirurgia , Feminino , Cálculos Biliares/cirurgia , Humanos , Imageamento por Ressonância Magnética , Dor Pós-Operatória/diagnóstico por imagem , Dor Pós-Operatória/cirurgia , Adulto JovemAssuntos
Intestino Delgado/diagnóstico por imagem , Intussuscepção/diagnóstico por imagem , Intussuscepção/cirurgia , Carcinoma de Células Renais/patologia , Carcinoma de Células Renais/cirurgia , Humanos , Neoplasias Intestinais/secundário , Intestino Delgado/patologia , Intestino Delgado/cirurgia , Neoplasias Renais/cirurgia , Laparotomia , Masculino , Anamnese , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios XRESUMO
BACKGROUND: Carcinoma is a rare complication of pharyngeal diverticula. There is a paucity of information about its incidence, presentation, management, and treatment outcomes. A systematic review and analysis of all reported cases has been carried out. METHODS: A comprehensive literature search for pharyngeal diverticula carcinoma was performed from 1896 to 2008. Descriptive analyses were carried out by analyzing the absolute and relative frequencies. Comparison of groups was illustrated with Kaplan-Meier curves and tested statistically using the log-rank test. A cohort of 56 patients with benign pharyngeal diverticula was selected for comparison with the accumulated cohort of pharyngeal diverticula carcinoma, and a Fisher's exact test was carried out on the extracted clinical characteristics of this cohort to evaluate for differences between benign and malignant pharyngeal diverticula. RESULTS: Forty-three articles reporting 60 cases satisfied the inclusion criteria. The mean age at presentation was 68.8 years (SD = 9.8 years). Five-year cancer-specific survival (CSS) rates for patients who underwent excision alone, excision + postoperative radiotherapy (PORT), and radiotherapy alone were 0.74 versus 0.63 versus 0.0, respectively (p = .39). Five-year CSS rates of patients <65 versus ≥65 years were 0.43 versus 0.78, respectively (p = .046). CONCLUSION: Irregular symptoms in benign diverticula should raise suspicion of malignancy. Management consists of surgical excision ± PORT. © 2014 Wiley Periodicals, Inc. Head Neck 36: 1368-1375, 2014.
Assuntos
Carcinoma , Neoplasias Faríngeas , Divertículo de Zenker , Carcinoma/diagnóstico , Carcinoma/epidemiologia , Carcinoma/terapia , Humanos , Neoplasias Faríngeas/diagnóstico , Neoplasias Faríngeas/epidemiologia , Neoplasias Faríngeas/terapiaAssuntos
Cegueira Cortical/etiologia , Eclampsia/diagnóstico , Síndrome da Leucoencefalopatia Posterior/diagnóstico , Síndrome da Leucoencefalopatia Posterior/etiologia , Adulto , Cegueira Cortical/diagnóstico , Cegueira Cortical/terapia , Eclampsia/terapia , Feminino , Humanos , Síndrome da Leucoencefalopatia Posterior/terapia , GravidezAssuntos
Síndrome de Marfan/diagnóstico , Valva Aórtica/cirurgia , Serviço Hospitalar de Emergência , Próteses Valvulares Cardíacas/efeitos adversos , Humanos , Masculino , Síndrome de Marfan/complicações , Pneumotórax/complicações , Pneumotórax/diagnóstico por imagem , Falha de Prótese/efeitos adversos , Radiografia , Escoliose/diagnóstico , Escoliose/etiologia , Adulto JovemRESUMO
BACKGROUND: Viagra and PDE-5 inhibitors use has mushroomed since its launch over a decade ago. A growing body of evidence indicates significant morbidity associated with the side effect profile of this class of drug. Hearing loss associated with PDE-5 inhibitor use has recently been reported, but few studies have evaluated the causal link. AIM: To review and scrutinise the current literature on the subject and propose possible physiologic mechanisms and to investigate the global reporting of this side effect. METHODS AND MATERIALS: Pharmacovigilance agencies around North America, Europe, and Australasia were contacted requesting reports of hearing loss associated with PDE-5 inhibitors. Reports were scrutinised to exclude those where others causes of hearing loss existed. RESULTS: Forty-seven cases of sensorineural hearing loss with a temporal association with PDE-5 inhibitor ingestion were obtained from both published literature and pharmacovigilance agencies. Cases had a mean age 56.6 years, male-to-female ratio of 7:1. Eighty-eight percent of reports were unilateral with an even left/right distribution. Hearing loss occurred within 24 hours of ingestion of PDE-5 inhibitor in 66.7% (n = 18) of cases. Sildenafil accounted for over 50% of cases. CONCLUSION: There is increasing evidence that PDE-5 inhibitors may induce sensorineural hearing loss via plausible physiological mechanisms. There needs to be more awareness of this disabling side effect among healthcare professionals responsible for prescribing this drug.