[Evaluation of systemic involving of the connective tissue in children with different localisation of isolated abnormal chords of the left ventricle (ACLV)].

Evaluation of the systemic involving of the connective tissue (SICT) under the new Ghent nosology (2010) showed that in children with isolated ACLV born to parents exposed to the Chernobyl disaster, its expression is associated with their location and quantity. The degree of systemic involvement of connective tissue is confirmed by the results of the analysis of features echostructure of isolated ACLV (the presence of thickening and calcification), echomorphometry, assessment of systolic (hypokinetic organization of the central hemodynamics), and the relaxation functions of the heart (initiation of diastolic dysfunction). High level of SICT (score greater than 5) indicates systemic damage to the body and particularly the heart, which requires dynamic monitoring and preventive measures. Found that the diagnostic and monitoring of children with isolated ACLV may be based on registration of systemic involvement of connective tissue with the calculation of points under the new Ghent nosology of 2010.

[Autonomic homeostasis of children born to parents irradiated in the result of the Chernobyl catastrophe with isolated abnormal chords of the left ventricle].

156 children of the main group (were born to parents irradiated in the result of Chernobyl disaster), in which according to Doppler echocardiography isolated abnormal chords of the left ventricle (AHLV) identified, 44 children of control group and 50 children of referent group were involved in the study Analysis of indicators of operational regulation of heart rate in children of primary group indicate the existence of autonomic dysregulation, which has the maximum expression in children with a threshold number of isolated abnormal chords. Evidence of autonomic dysregulation in children born to parents irradiated in the result of the Chernobyl disaster with isolated AHLV requires primary and secondary prevention to reduce the frequency of unfavourable clinical course.

[Analysis of structural and functional indices of the children hearts with isolated abnormal chords of the left ventricle and who were born to parents irradiated during the Chernobyl accident].

156 children of the main group, born to parents irradiated in the result of Chernobyl disaster have been involved in the study. These children were identified with isolated abnormal chords of the left ventricle (AHLV) according the results of Doppler echocardiography. 39 practically healthy children and 24 children of the nosology control group have also been observed. Threshold quantity of AHLV were determined in 33 children, main group, (subgroup Ia), sub-threshold--in 123 children (subgroup I(B)). The children of the control group with threshold quantity of AHLV were found with decreased adaptation capacity of the cardio-vascular system through shifts in dynamics and energetics of the heart contraction. Reduction in systolic output, systolic and heart indices justify hypokinetic type of organization of central hemodynamics, which can be considered an early sign of tension of functional capabilities of the heart and blood vessels. This subgroup of children was found to have changes of transmitral blood flow indicating the initiation of the heart's diastolic dysfunction. Almost 1/3 of children with subthreshold number of AHLV were also revealed to have signs of initiation of the heart's diastolic dysfunction.

[Abnormal chords of the left ventricle].

The analysis of literature data has showed that evaluation of prognostic significance of abnormal chords of the left ventricle (ACLV) is ambiguous. It remains an open question on the participation of ACLV in the pathogenesis of cardiovascular disease. Obviously, the prognosis of ACLV is determined not so much by the fact of its existence, as degree of connective tissue dysplasia, the number and topic of anomalous chords, the presence of hemodynamic and/or arrhythmic complications. Identification and verification of the anomalous intracavitary structures are important, because they often serve as potential sources of echodiagnostic mistakes, for they can mask more important pathological findings.

[System of collection and dynamic processing of information for predicting population genetics]. / Systema zboru ta dynamichnoï obrobky informatsiï dlia prognozuvannia genetychnykh protsesiv u populiatsiï liudyny.

Creation has come to be necessary in Ukraine of a system for collection, dynamic supply and processing of information about genetical processes. Such a system as that described above is submitted by the authors. The basis of the system is a module in which, by using special units and connections between them, a collection, storing, and processing of information about genetic pathological processes in the time-related course is to be carried on together with prognostication thereof in the population of the country as a whole or in each region taken separately.

[An approach to genetic monitoring via a genetic registry]. / Pidkhid do henetychnoho monitorynhu cherez henetychnyi reiestr.

The analysis of the selective excerpt of the children with the inherited disorders has been made on the basis of the Kiev Medical Genetic Center, where the regional anonymous syndromological computer register has been organized. Register's file during 1993-96 has the information about 883 families that has a genetically ill proband. Genetic syndrome has been diagnosed in 78.02% (105 nosological points). The information taken from the register has allowed for the first time to distinguish the inherited pathology from the acquired one, so the new mutation from 30.23% out of all registered inherited disease. The necessity of the creation of the National Genetic Register in the Ukraine and the new conception of the two-stage genetical monitoring of the population has been proved.

[Genetic or ecogenetic consequences of the Chernobyl accident? (facts and hypotheses)]. / Henetychni chy ekohenetychni naslidky Chornobyl's'koï avariï? (fakty ta hipotezy).

The results of investigations indicated the necessity of genetic monitoring in population using the data of family examination in medical genetic centres. Indices of the frequency of developmental abnormalities in newborns are not suitable for monitoring because they do not permit to differentiate between new mutations and inherited ones. The dissemination of these abnormalities among newborns in Kiev mostly coincides with the same index in other European regions and is lower than in Canada and West Australia. According to the data of Kiev regional medical genetics centre, about 80% of developmental abnormalities occur as a result of inherited mutations but not new ones. Under the conditions of environmental pollution, ecogenetic consequences assume a new importance.